Therapeutic effect of topical administration of red onion extract in a murine model of allergic rhinitis

Min Young Seo, Ki Ryung Kim, Jung Joo Lee, Gwanghui Ryu, Seung Hoon Lee, Sang Duk Hong, Hun Jong Dhong, Chung Hwan Baek, Seung Kyu Chung, Hyo Yeol Kim

Research output: Contribution to journalArticle

Abstract

The aim of this study was to evaluate the effect of topical administration of onion (Allium cepa) extract on nasal cavity for treatment of allergic rhinitis (AR). BALB/c mice were sensitized by intraperitoneal injection of ovalbumin (OVA) and challenged with intranasal instillation of OVA with or without onion extracts for five times a week on 3 consecutive weeks. Allergic symptom score according to frequencies of sneezing, serum total and OVA specific immunoglobulin E (IgE) level, cytokine levels of nasal mucosa and eosinophilic infiltration were analyzed. Allergic symptom score, serum total and OVA specific IgE, cytokine levels of nasal mucosa (interleukin (IL)-4, IL-5, IL-10, IL-13, IFN-γ, TNF-α and COX-2) and eosinophilic infiltration were higher in allergic mouse group than negative control group. Topical application of onion extracts significantly reduced allergic symptoms and OVA specific IgE levels. Cytokine levels of IL-4, IL-5, IL-10, IL-13 and IFN-γ were significantly decreased in groups treated with onion extract. In addition, eosinophil infiltration of nasal turbinate mucosa was also significantly decreased after treatment with onion extract. Topical administration of onion extract significantly reduces allergic rhinitis symptom and allergic inflammatory reaction in a murine allergic model. It can be assumed that the topical application of onion extract regulates allergic symptoms by suppressing the type-1 helper (Th1) and type-2 helper (Th2) responses and reducing the allergic inflammatory reaction.

Original languageEnglish
Article number2883
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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Topical Administration
Onions
Therapeutic Uses
Ovalbumin
Nasal Mucosa
Immunoglobulin E
Interleukin-13
Interleukin-5
Cytokines
Interleukin-4
Interleukin-10
Hypersensitivity
Sneezing
Turbinates
Allergic Rhinitis
Nasal Cavity
Intraperitoneal Injections
Serum
Eosinophils
Control Groups

ASJC Scopus subject areas

  • General

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Therapeutic effect of topical administration of red onion extract in a murine model of allergic rhinitis. / Seo, Min Young; Kim, Ki Ryung; Lee, Jung Joo; Ryu, Gwanghui; Lee, Seung Hoon; Hong, Sang Duk; Dhong, Hun Jong; Baek, Chung Hwan; Chung, Seung Kyu; Kim, Hyo Yeol.

In: Scientific Reports, Vol. 9, No. 1, 2883, 01.12.2019.

Research output: Contribution to journalArticle

Seo, MY, Kim, KR, Lee, JJ, Ryu, G, Lee, SH, Hong, SD, Dhong, HJ, Baek, CH, Chung, SK & Kim, HY 2019, 'Therapeutic effect of topical administration of red onion extract in a murine model of allergic rhinitis', Scientific Reports, vol. 9, no. 1, 2883. https://doi.org/10.1038/s41598-019-39379-9
Seo, Min Young ; Kim, Ki Ryung ; Lee, Jung Joo ; Ryu, Gwanghui ; Lee, Seung Hoon ; Hong, Sang Duk ; Dhong, Hun Jong ; Baek, Chung Hwan ; Chung, Seung Kyu ; Kim, Hyo Yeol. / Therapeutic effect of topical administration of red onion extract in a murine model of allergic rhinitis. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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