Therapeutic potential of α,β-thujone through metabolic reprogramming and caspase-dependent apoptosis in ovarian cancer cells

Jin Young Lee, Hahyun Park, Whasun Lim, Gwonhwa Song

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The therapeutic potential of α,β-thujone, a functional compound found in many medicinal plants of the Cupressaceae, Asteraceae, and Lamiaceae families, has been demonstrated, including in inflammation and cancers. However, its pharmacological functions and mechanisms of action in ovarian cancer remain unclear. We investigated the anticancer properties of α,β-thujone in ES2 and OV90 human ovarian cancer cells and its effect on sensitization to cisplatin. α,β-thujone inhibited cancer cell proliferation and induced cell death through caspase-dependent intrinsic apoptotic pathways. Moreover, α,β-thujone-mediated endoplasmic reticulum stress was associated with the loss of mitochondrial functions and altered metabolic landscape of ovarian cancer cells. α,β-Thujone attenuated blood vessel formation in transgenic zebrafish, implying it has significant antiangiogenic potential. In addition, α,β-thujone sensitized ovarian cancer cells to cisplatin, causing synergistic pharmacological effects. Collectively, our results suggest that α,β-thujone has therapeutic potential in human ovarian cancer and functions via regulating multiple intracellular stress-associated metabolic reprogramming and caspase-dependent apoptotic pathways.

Original languageEnglish
Pages (from-to)1545-1558
Number of pages14
JournalJournal of Cellular Physiology
Volume236
Issue number2
DOIs
Publication statusPublished - 2021 Feb

Keywords

  • apoptosis
  • metabolic reprogramming
  • ovarian cancer
  • zebrafish
  • α
  • β-thujone

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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