TY - JOUR
T1 - Therapeutic potential of ectopic olfactory and taste receptors
AU - Lee, Sung Joon
AU - Depoortere, Inge
AU - Hatt, Hanns
N1 - Funding Information:
The authors thank C. Wu and Y.-J. Kim for assistance in manuscript preparations. This work was supported by a grant from the National Research Foundation (NRF) of Korea (NRF-2018R1A4A1022589 and 2016R1A2A2A05005483), funded by the South Korean government (MSIP), and was supported by a grant from the University of Leuven (Methusalem grant) and Research Foundation Flanders (G073615N).
Publisher Copyright:
© 2018, Springer Nature Limited.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.
AB - Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.
UR - http://www.scopus.com/inward/record.url?scp=85057608290&partnerID=8YFLogxK
U2 - 10.1038/s41573-018-0002-3
DO - 10.1038/s41573-018-0002-3
M3 - Review article
C2 - 30504792
AN - SCOPUS:85057608290
VL - 18
SP - 116
EP - 138
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
SN - 1474-1776
IS - 2
ER -
