Abstract
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.
| Original language | English |
|---|---|
| Journal | Nature Reviews Drug Discovery |
| DOIs | |
| Publication status | Accepted/In press - 2018 Jan 1 |
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ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
Cite this
Therapeutic potential of ectopic olfactory and taste receptors. / Lee, Sung-Joon; Depoortere, Inge; Hatt, Hanns.
In: Nature Reviews Drug Discovery, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapeutic potential of ectopic olfactory and taste receptors
AU - Lee, Sung-Joon
AU - Depoortere, Inge
AU - Hatt, Hanns
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.
AB - Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.
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UR - http://www.scopus.com/inward/citedby.url?scp=85057608290&partnerID=8YFLogxK
U2 - 10.1038/s41573-018-0002-3
DO - 10.1038/s41573-018-0002-3
M3 - Article
C2 - 30504792
AN - SCOPUS:85057608290
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
SN - 1474-1776
ER -