Therapeutic potential of ectopic olfactory and taste receptors

Sung-Joon Lee; Inge Depoortere; Hanns Hatt

doi:10.1038/s41573-018-0002-3

Therapeutic potential of ectopic olfactory and taste receptors

Sung-Joon Lee, Inge Depoortere, Hanns Hatt

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.

Original language	English
Journal	Nature Reviews Drug Discovery
DOIs	https://doi.org/10.1038/s41573-018-0002-3
Publication status	Accepted/In press - 2018 Jan 1

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Therapeutic potential of ectopic olfactory and taste receptors

Abstract

ASJC Scopus subject areas

UN SDGs

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