Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets

Junhu Tai, Munsoo Han, Taehoon Kim

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Chronic rhinosinusitis is a chronic inflammatory disease of the upper airways, for which treatment options include medical or surgical therapy. However, there are limitations to conservative treatment strategies, such as the relapse of nasal polyps. In this review, we discuss the rising role of biomolecular mechanisms associated with various biologics that have been approved or are undergoing clinical trials to treat chronic rhinosinusitis. We also highlight the potential molecular therapeutic targets for managing and treating chronic rhinosinusitis.

Original languageEnglish
Article number5523
JournalInternational journal of molecular sciences
Volume23
Issue number10
DOIs
Publication statusPublished - 2022 May 1

Keywords

  • biologics
  • chronic rhinosinusitis
  • immunity
  • monoclonal antibody
  • therapeutic strategy

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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