There is no evidence for an association between the serotonin receptor 3A gene C178T polymorphism and tardive dyskinesia in Korean schizophrenia patients

Seung Gul Kang, Heon Jeong Lee, Ho Kyoung Yoon, Sung Nam Cho, Young Min Park, Leen Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Tardive dyskinesia (TD) is a potential adverse effect of long-term treatment with antipsychotics. Previous studies have suggested a link between brain serotonergic systems and TD vulnerability. A recent report described that a serotonin 3 receptor (5-HTR3) agonist induced rhythmic movements in mice with complete paraplegia. Furthermore, it has been reported that the 5-HTR3 antagonist ondansetron is efficacious in the treatment of Gilles de la Tourette syndrome (GTS). Aim: The aim of the present study was to determine whether the 5-HTR3A gene C178T polymorphism is associated with antipsychotic-induced TD in Korean schizophrenia patients. Methods: We investigated 280 Korean schizophrenia patients. Subjects with TD (n = 105) and without TD (n = 175) were matched for antipsychotic drug exposure and other relevant variables. Results: The distributions of genotypic (chi-squared = 3.55, p = 0.169) and allelic (chi-squared = 0.40, p = 0.528) frequencies did not differ between patients with and without TD. The total score on the Abnormal Involuntary Movement Scale also did not differ between the two genotype groups (F = 0.94, p = 0.391). Conclusions: The findings of the present study do not support the involvement of the 5-HTR3A gene C178T polymorphism in TD in Korean schizophrenia subjects.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalNordic Journal of Psychiatry
Volume67
Issue number3
DOIs
Publication statusPublished - 2013 Jun

Keywords

  • Association
  • Polymorphism
  • Schizophrenia
  • Serotonin receptor 3A gene
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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