Thermosensitive and mucoadhesive delivery systems of mucosal vaccines

In Kwon Han, Young Bong Kim, Hung Sik Kang, Donggeun Sul, Woon Won Jung, Hee Jeong Cho, Yu Kyoung Oh

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)

    Abstract

    Mucosal vaccination is emerging as a potential administration route for eliciting antigen-specific mucosal and systemic immunogenicity. Most mucosal vaccines have been administered in a phosphate-buffered saline vehicle that may limit the exposure of antigens to the mucosal surfaces and result in poor immunogenicity. To improve the potency of the mucosal vaccines, we have developed mucosal vaccine delivery systems that might prevent leakage and increase retention of vaccines on mucosal surfaces. Thermosensitive polymers have been used to reduce the leakage problems of nasal or vaginal vaccines, while mucoadhesive polymers have been employed to increase the mucosal contact of the vaccines. Here, we describe the formulation and delivery methods of mucosal vaccines using thermosensitive and mucoadhesive polymers.

    Original languageEnglish
    Pages (from-to)106-111
    Number of pages6
    JournalMethods
    Volume38
    Issue number2
    DOIs
    Publication statusPublished - 2006 Feb

    Keywords

    • Delivery systems
    • Mucoadhesive
    • Mucosal
    • Nasal
    • Thermosensitive
    • Vaginal

    ASJC Scopus subject areas

    • Molecular Biology
    • Biochemistry, Genetics and Molecular Biology(all)

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