Thermosensitive and mucoadhesive delivery systems of mucosal vaccines

In Kwon Han, Young Bong Kim, Hung Sik Kang, Donggeun Sul, Woon Won Jung, Hee Jeong Cho, Yu Kyoung Oh

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Mucosal vaccination is emerging as a potential administration route for eliciting antigen-specific mucosal and systemic immunogenicity. Most mucosal vaccines have been administered in a phosphate-buffered saline vehicle that may limit the exposure of antigens to the mucosal surfaces and result in poor immunogenicity. To improve the potency of the mucosal vaccines, we have developed mucosal vaccine delivery systems that might prevent leakage and increase retention of vaccines on mucosal surfaces. Thermosensitive polymers have been used to reduce the leakage problems of nasal or vaginal vaccines, while mucoadhesive polymers have been employed to increase the mucosal contact of the vaccines. Here, we describe the formulation and delivery methods of mucosal vaccines using thermosensitive and mucoadhesive polymers.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalMethods
Volume38
Issue number2
DOIs
Publication statusPublished - 2006 Feb

Keywords

  • Delivery systems
  • Mucoadhesive
  • Mucosal
  • Nasal
  • Thermosensitive
  • Vaginal

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)

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