Thermostable cellulases: Current status and perspectives

Anil K. Patel, Reeta Rani Singhania, Sang Jun Sim, Ashok Pandey

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

It is envisaged that the utilization of lignocellulosic biomass for ethanol production for transport sector, would make cellulases the most demanded industrial enzyme. The greatest potential of cellulolytic enzymes lies in ethanol production from biomass by enzymatic hydrolysis of cellulose but low thermostability and low titer of cellulase production resulting into high cost of the enzyme which is the major set-back. A number of research groups are working on cellulase to improve its thermostability so as to be able to perform hydrolysis at elevated temperatures which would eventually increase the efficiency of cellulose hydrolysis. The technologies developed from lignocellulosic biomass via cellulose hydrolysis promise environmental and economical sustainability in the long run along with non-dependence on nonrenewable energy source. This review deals with the important sources of thermostable cellulases, mechanism, its regulation, strategies to enhance the thermostability further with respect to its importance for biofuel applications.

Original languageEnglish
Pages (from-to)385-392
Number of pages8
JournalBioresource Technology
Volume279
DOIs
Publication statusPublished - 2019 May 1

Fingerprint

Cellulases
Cellulose
hydrolysis
Hydrolysis
Biomass
Enzymes
Cellulase
cellulose
Ethanol
enzyme
ethanol
biomass
Enzymatic hydrolysis
Biofuels
Sustainable development
biofuel
sustainability
Costs
cost
Temperature

Keywords

  • Bioethanol
  • Cellulases
  • Lignocellulose biomass
  • Thermophiles
  • Thermostability

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal

Cite this

Thermostable cellulases : Current status and perspectives. / Patel, Anil K.; Singhania, Reeta Rani; Sim, Sang Jun; Pandey, Ashok.

In: Bioresource Technology, Vol. 279, 01.05.2019, p. 385-392.

Research output: Contribution to journalReview article

Patel, Anil K. ; Singhania, Reeta Rani ; Sim, Sang Jun ; Pandey, Ashok. / Thermostable cellulases : Current status and perspectives. In: Bioresource Technology. 2019 ; Vol. 279. pp. 385-392.
@article{3f6781eeed484e37a732f0e856aae77a,
title = "Thermostable cellulases: Current status and perspectives",
abstract = "It is envisaged that the utilization of lignocellulosic biomass for ethanol production for transport sector, would make cellulases the most demanded industrial enzyme. The greatest potential of cellulolytic enzymes lies in ethanol production from biomass by enzymatic hydrolysis of cellulose but low thermostability and low titer of cellulase production resulting into high cost of the enzyme which is the major set-back. A number of research groups are working on cellulase to improve its thermostability so as to be able to perform hydrolysis at elevated temperatures which would eventually increase the efficiency of cellulose hydrolysis. The technologies developed from lignocellulosic biomass via cellulose hydrolysis promise environmental and economical sustainability in the long run along with non-dependence on nonrenewable energy source. This review deals with the important sources of thermostable cellulases, mechanism, its regulation, strategies to enhance the thermostability further with respect to its importance for biofuel applications.",
keywords = "Bioethanol, Cellulases, Lignocellulose biomass, Thermophiles, Thermostability",
author = "Patel, {Anil K.} and Singhania, {Reeta Rani} and Sim, {Sang Jun} and Ashok Pandey",
year = "2019",
month = "5",
day = "1",
doi = "10.1016/j.biortech.2019.01.049",
language = "English",
volume = "279",
pages = "385--392",
journal = "Bioresource Technology",
issn = "0960-8524",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Thermostable cellulases

T2 - Current status and perspectives

AU - Patel, Anil K.

AU - Singhania, Reeta Rani

AU - Sim, Sang Jun

AU - Pandey, Ashok

PY - 2019/5/1

Y1 - 2019/5/1

N2 - It is envisaged that the utilization of lignocellulosic biomass for ethanol production for transport sector, would make cellulases the most demanded industrial enzyme. The greatest potential of cellulolytic enzymes lies in ethanol production from biomass by enzymatic hydrolysis of cellulose but low thermostability and low titer of cellulase production resulting into high cost of the enzyme which is the major set-back. A number of research groups are working on cellulase to improve its thermostability so as to be able to perform hydrolysis at elevated temperatures which would eventually increase the efficiency of cellulose hydrolysis. The technologies developed from lignocellulosic biomass via cellulose hydrolysis promise environmental and economical sustainability in the long run along with non-dependence on nonrenewable energy source. This review deals with the important sources of thermostable cellulases, mechanism, its regulation, strategies to enhance the thermostability further with respect to its importance for biofuel applications.

AB - It is envisaged that the utilization of lignocellulosic biomass for ethanol production for transport sector, would make cellulases the most demanded industrial enzyme. The greatest potential of cellulolytic enzymes lies in ethanol production from biomass by enzymatic hydrolysis of cellulose but low thermostability and low titer of cellulase production resulting into high cost of the enzyme which is the major set-back. A number of research groups are working on cellulase to improve its thermostability so as to be able to perform hydrolysis at elevated temperatures which would eventually increase the efficiency of cellulose hydrolysis. The technologies developed from lignocellulosic biomass via cellulose hydrolysis promise environmental and economical sustainability in the long run along with non-dependence on nonrenewable energy source. This review deals with the important sources of thermostable cellulases, mechanism, its regulation, strategies to enhance the thermostability further with respect to its importance for biofuel applications.

KW - Bioethanol

KW - Cellulases

KW - Lignocellulose biomass

KW - Thermophiles

KW - Thermostability

UR - http://www.scopus.com/inward/record.url?scp=85060331503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060331503&partnerID=8YFLogxK

U2 - 10.1016/j.biortech.2019.01.049

DO - 10.1016/j.biortech.2019.01.049

M3 - Review article

C2 - 30685132

AN - SCOPUS:85060331503

VL - 279

SP - 385

EP - 392

JO - Bioresource Technology

JF - Bioresource Technology

SN - 0960-8524

ER -