Three-dimensional cell-hydrogel printer using electromechanical microvalve for tissue engineering

W. Lee, V. K. Lee, S. Polio, K. Fischer, J. H. Lee, J. K. Park, S. S. Yoo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

In this study, we report a newly developed three-dimensional (3D) biological printer using non-contact, electromechanical microvalves with a nozzle diameter of 150 μm. To control and utilize this printer for life science applications, we developed an easy-to-use control software with a graphic user interface (GUI). First, using the printer, we tested the viability of dispensed mammalian cells after printing, and there was no significant difference in viability between dispensed cells and conventionally plated cells. Next, we constructed a 3D hydrogel scaffold by printing collagen hydrogel precursor layer-by-layer with linear patterns of gelatin inside. Using the same scheme, neurons were printed and patterned in multi-layered collagen scaffold. The on-demand capability to print cells and hydrogels in multi-layered hydrogel scaffold offers flexibility in generating artificial 3D tissue composites.

Original languageEnglish
Title of host publicationTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages2230-2233
Number of pages4
DOIs
Publication statusPublished - 2009
EventTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States
Duration: 2009 Jun 212009 Jun 25

Publication series

NameTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

OtherTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
CountryUnited States
CityDenver, CO
Period09/6/2109/6/25

Keywords

  • 3D freeform fabrication
  • Cell printing
  • Electromechanical microvalve
  • Hydrogel scaffold
  • Tissue engineering

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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  • Cite this

    Lee, W., Lee, V. K., Polio, S., Fischer, K., Lee, J. H., Park, J. K., & Yoo, S. S. (2009). Three-dimensional cell-hydrogel printer using electromechanical microvalve for tissue engineering. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 2230-2233). [5285591] (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2009.5285591