Three-dimensional configuration of subretinal fluid in central serous chorioretinopathy

Soh Eun Ahn, Jae Ryung Oh, Jong Hyun Oh, In Kyung Oh, Seong-Woo Kim, Kuhl Huh

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

PURPOSE. The purpose of this study was to characterize the 3-dimensional (3D) configuration of subretinal fluid (SRF) in idiopathic central serous chorioretinopathy (CSC) using spectral-domain optical coherence tomography (SDOCT). METHODS. The OCT images of patients with CSC were reviewed retrospectively. The 3D configurations of SRF were assessed using a modified segmentation algorithm of SDOCT. The differences of the configurations between acute and chronic CSC were compared. For the patients with acute CSC, we investigated a possible relationship between early change in 3D configuration and disease prognosis. RESULTS. We included 69 eyes of 68 patients in this study. The mean volume, the greatest basal diameter (GBD), and the area of SRF were not different between acute and chronic CSC. The mean peak height (PH) of SRF and the ratio of PH to GBD in acute CSC (298.13 ± 92.67 lm, 9.44 ± 2.57%) were significantly greater than those in chronic CSC (192.97 ± 71.05 lm, 5.97 ± 1.90%; P < 0.001, P < 0.001, respectively). In patients with acute CSC, the early changing pattern of 3D configurations was significantly different according to the SRF prognosis (P = 0.003). In situ decrease of SRF was observed in 94.7% of the spontaneously resolving group. However, downward elongation of SRF was observed more frequently in the persistent group (58.3%) than in the spontaneously resolving group (6.3%). CONCLUSIONS. The 3D configurations of SRF were different between acute and chronic CSC. In patients with acute onset, the early change of 3D configuration was different and varied according to the SRF prognosis.

Original languageEnglish
Pages (from-to)5944-5952
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume54
Issue number9
DOIs
Publication statusPublished - 2013 Sep 23

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Central Serous Chorioretinopathy
Subretinal Fluid
Optical Coherence Tomography

Keywords

  • Central serous chorioretinopathy
  • Optical coherence tomography
  • Subretinal fluid
  • Three-dimensional configuration

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Three-dimensional configuration of subretinal fluid in central serous chorioretinopathy. / Ahn, Soh Eun; Oh, Jae Ryung; Oh, Jong Hyun; Oh, In Kyung; Kim, Seong-Woo; Huh, Kuhl.

In: Investigative Ophthalmology and Visual Science, Vol. 54, No. 9, 23.09.2013, p. 5944-5952.

Research output: Contribution to journalArticle

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abstract = "PURPOSE. The purpose of this study was to characterize the 3-dimensional (3D) configuration of subretinal fluid (SRF) in idiopathic central serous chorioretinopathy (CSC) using spectral-domain optical coherence tomography (SDOCT). METHODS. The OCT images of patients with CSC were reviewed retrospectively. The 3D configurations of SRF were assessed using a modified segmentation algorithm of SDOCT. The differences of the configurations between acute and chronic CSC were compared. For the patients with acute CSC, we investigated a possible relationship between early change in 3D configuration and disease prognosis. RESULTS. We included 69 eyes of 68 patients in this study. The mean volume, the greatest basal diameter (GBD), and the area of SRF were not different between acute and chronic CSC. The mean peak height (PH) of SRF and the ratio of PH to GBD in acute CSC (298.13 ± 92.67 lm, 9.44 ± 2.57{\%}) were significantly greater than those in chronic CSC (192.97 ± 71.05 lm, 5.97 ± 1.90{\%}; P < 0.001, P < 0.001, respectively). In patients with acute CSC, the early changing pattern of 3D configurations was significantly different according to the SRF prognosis (P = 0.003). In situ decrease of SRF was observed in 94.7{\%} of the spontaneously resolving group. However, downward elongation of SRF was observed more frequently in the persistent group (58.3{\%}) than in the spontaneously resolving group (6.3{\%}). CONCLUSIONS. The 3D configurations of SRF were different between acute and chronic CSC. In patients with acute onset, the early change of 3D configuration was different and varied according to the SRF prognosis.",
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AU - Oh, Jae Ryung

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AU - Kim, Seong-Woo

AU - Huh, Kuhl

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N2 - PURPOSE. The purpose of this study was to characterize the 3-dimensional (3D) configuration of subretinal fluid (SRF) in idiopathic central serous chorioretinopathy (CSC) using spectral-domain optical coherence tomography (SDOCT). METHODS. The OCT images of patients with CSC were reviewed retrospectively. The 3D configurations of SRF were assessed using a modified segmentation algorithm of SDOCT. The differences of the configurations between acute and chronic CSC were compared. For the patients with acute CSC, we investigated a possible relationship between early change in 3D configuration and disease prognosis. RESULTS. We included 69 eyes of 68 patients in this study. The mean volume, the greatest basal diameter (GBD), and the area of SRF were not different between acute and chronic CSC. The mean peak height (PH) of SRF and the ratio of PH to GBD in acute CSC (298.13 ± 92.67 lm, 9.44 ± 2.57%) were significantly greater than those in chronic CSC (192.97 ± 71.05 lm, 5.97 ± 1.90%; P < 0.001, P < 0.001, respectively). In patients with acute CSC, the early changing pattern of 3D configurations was significantly different according to the SRF prognosis (P = 0.003). In situ decrease of SRF was observed in 94.7% of the spontaneously resolving group. However, downward elongation of SRF was observed more frequently in the persistent group (58.3%) than in the spontaneously resolving group (6.3%). CONCLUSIONS. The 3D configurations of SRF were different between acute and chronic CSC. In patients with acute onset, the early change of 3D configuration was different and varied according to the SRF prognosis.

AB - PURPOSE. The purpose of this study was to characterize the 3-dimensional (3D) configuration of subretinal fluid (SRF) in idiopathic central serous chorioretinopathy (CSC) using spectral-domain optical coherence tomography (SDOCT). METHODS. The OCT images of patients with CSC were reviewed retrospectively. The 3D configurations of SRF were assessed using a modified segmentation algorithm of SDOCT. The differences of the configurations between acute and chronic CSC were compared. For the patients with acute CSC, we investigated a possible relationship between early change in 3D configuration and disease prognosis. RESULTS. We included 69 eyes of 68 patients in this study. The mean volume, the greatest basal diameter (GBD), and the area of SRF were not different between acute and chronic CSC. The mean peak height (PH) of SRF and the ratio of PH to GBD in acute CSC (298.13 ± 92.67 lm, 9.44 ± 2.57%) were significantly greater than those in chronic CSC (192.97 ± 71.05 lm, 5.97 ± 1.90%; P < 0.001, P < 0.001, respectively). In patients with acute CSC, the early changing pattern of 3D configurations was significantly different according to the SRF prognosis (P = 0.003). In situ decrease of SRF was observed in 94.7% of the spontaneously resolving group. However, downward elongation of SRF was observed more frequently in the persistent group (58.3%) than in the spontaneously resolving group (6.3%). CONCLUSIONS. The 3D configurations of SRF were different between acute and chronic CSC. In patients with acute onset, the early change of 3D configuration was different and varied according to the SRF prognosis.

KW - Central serous chorioretinopathy

KW - Optical coherence tomography

KW - Subretinal fluid

KW - Three-dimensional configuration

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