Three dimensional, sheathless, and high-throughput microparticle inertial focusing through geometry-induced secondary flows

Aram Chung, Daniel R. Gossett, Dino Di Carlo

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

A novel inertial focusing platform creates a single-stream microparticle train in a single-focal plane without sheath fluids and external forces, all in a high-throughput manner. The proposed design consists of a low-aspect-ratio straight channel interspersed with a series of constrictions in height arranged orthogonally, making use of inertial focusing and geometry-induced secondary flows. Focusing efficiency as high as 99.77% is demonstrated with throughput as high as 36 000 particles s-1 for a variety of different sized particles and cells.

Original languageEnglish
Pages (from-to)685-690
Number of pages6
JournalSmall
Volume9
Issue number5
DOIs
Publication statusPublished - 2013 Mar 11
Externally publishedYes

Keywords

  • flow cytometry
  • fluid dynamics
  • inertial focusing
  • microfluidics
  • microparticle focusing

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Engineering (miscellaneous)

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