Aim: To screen for and determine cognitive dysfunction, cognitive tests and/or informant reports are commonly used. However, these cognitive tests and informant reports are not always available. The present study investigated three screening methods using the Mini-Mental State Examination (MMSE) as the cognitive test, and the Korean dementia screening questionnaire (KDSQ) as the informant report. Methods: Participants were recruited from the Korea Clinical Research Center for Dementia of South Korea, and included 2861 patients with Alzheimer's disease (dementia), 3519 patients with mild cognitive impairment and 1375 controls with no cognitive dysfunction. Three screening methods were tested: (i) MMSE alone (MMSEcut-off); (ii) a conventional combination of MMSE and KDSQ (MMSE+KDSQcut-off); and (iii) a decision tree with MMSE and KDSQ (MMSE+KDSQdecision tree). Results: For discriminating any cognitive dysfunction from controls, MMSE+KDSQcut-off had the highest area under the receiver operating characteristic curve (0.784). For discriminating dementia from controls, MMSE+KDSQcut-off had the highest area under the receiver operating characteristic curve (0.899). For discriminating mild cognitive impairment from controls, MMSEcut-off had the highest area under the receiver operating characteristic curve (0.683). MMSE+KDSQdecision tree showed the highest sensitivity for all discriminations. For overall classification accuracy, MMSE+KDSQdecision tree had the highest value (70.0%). Conclusions: These three methods had different advantageous properties for screening and staging cognitive dysfunction. As there might be different availability across clinical settings, these three methods can be selected and used according to situational needs. Geriatr Gerontol Int 2016; 16: 252-258.
- Cognitive dysfunction
- Korean dementia screening questionnaire
- Mini-Mental State Examination
ASJC Scopus subject areas
- Health(social science)
- Geriatrics and Gerontology