Three-year follow-up of patients with acetylcholine-induced coronary artery spasm combined with insignificant coronary stenosis

Byoung Geol Choi, Sung Hun Park, Seung-Woon Rha, Jihun Ahn, Se Yeon Choi, Jae Kyeong Byun, Hu Li, Ahmed Mashaly, Min Suk Shim, Jun Hyuk Kang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Sunki Lee, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog SeoDong Joo Oh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background Coronary artery spasm (CAS) and significant coronary stenosis are known to be major causes of myocardial ischemia. However, their association and the impact of insignificant coronary stenosis (ICS) on long-term clinical outcomes of CAS patients are largely unknown. Methods A total of 2797 patients without significant coronary artery disease (CAD) who underwent the acetylcholine (ACH) provocation test between November 2004 and October 2010 were enrolled. Significant CAS was defined as having ≥ 70% of temporary narrowing by ACH test and ICS as having < 70% of fixed stenosis on angiography. Patients were divided into two groups: ICS group (n = 764) and non-ICS group (n = 845). To adjust potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. Primary endpoint was the composite of total death, myocardial infraction (MI), de novo percutaneous coronary intervention (PCI), and cerebrovascular accidents (CVA). Secondary endpoint was the incidence of recurrent angina requiring repeat coronary angiography (CAG) at 3 years. Results After PSM analysis, two well-balanced groups (548 pairs, total = 1096) were generated. The baseline clinical characteristics were similar between the two groups. During the ACH test, compared with the non-ICS group, the ICS group had smaller spastic narrowing diameter (0.69 ± 0.35 vs. 0.73 ± 0.37, P = 0.039) and incidence of ST-segment depression (4.0% vs. 0.9%, P = 0.001). The incidence of primary and secondary endpoints was similar between the two groups up to 3 years. Conclusions Although, the ICS group was expected to have more adverse long-term clinical outcomes, it was not associated with the increased incidence of major adverse clinical outcomes compared with the non-ICS group up to 3 years. Longer term follow-up studies are needed.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalInternational Journal of Cardiology
Volume238
DOIs
Publication statusPublished - 2017 Jul 1

Fingerprint

Coronary Stenosis
Spasm
Acetylcholine
Coronary Vessels
Propensity Score
Incidence
Logistic Models
Muscle Spasticity
Percutaneous Coronary Intervention
Coronary Angiography
Myocardial Ischemia
Coronary Artery Disease
Angiography
Pathologic Constriction
Stroke

Keywords

  • Acetylcholine provocation test
  • Coronary artery spasm
  • Coronary artery stenosis

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Three-year follow-up of patients with acetylcholine-induced coronary artery spasm combined with insignificant coronary stenosis. / Choi, Byoung Geol; Park, Sung Hun; Rha, Seung-Woon; Ahn, Jihun; Choi, Se Yeon; Byun, Jae Kyeong; Li, Hu; Mashaly, Ahmed; Shim, Min Suk; Kang, Jun Hyuk; Kim, Woohyeun; Choi, Jah Yeon; Park, Eun Jin; Lee, Sunki; Na, Jin Oh; Choi, Cheol Ung; Lim, Hong Euy; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo.

In: International Journal of Cardiology, Vol. 238, 01.07.2017, p. 66-71.

Research output: Contribution to journalArticle

Choi, Byoung Geol ; Park, Sung Hun ; Rha, Seung-Woon ; Ahn, Jihun ; Choi, Se Yeon ; Byun, Jae Kyeong ; Li, Hu ; Mashaly, Ahmed ; Shim, Min Suk ; Kang, Jun Hyuk ; Kim, Woohyeun ; Choi, Jah Yeon ; Park, Eun Jin ; Lee, Sunki ; Na, Jin Oh ; Choi, Cheol Ung ; Lim, Hong Euy ; Kim, Eung Ju ; Park, Chang Gyu ; Seo, Hong Seog ; Oh, Dong Joo. / Three-year follow-up of patients with acetylcholine-induced coronary artery spasm combined with insignificant coronary stenosis. In: International Journal of Cardiology. 2017 ; Vol. 238. pp. 66-71.
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abstract = "Background Coronary artery spasm (CAS) and significant coronary stenosis are known to be major causes of myocardial ischemia. However, their association and the impact of insignificant coronary stenosis (ICS) on long-term clinical outcomes of CAS patients are largely unknown. Methods A total of 2797 patients without significant coronary artery disease (CAD) who underwent the acetylcholine (ACH) provocation test between November 2004 and October 2010 were enrolled. Significant CAS was defined as having ≥ 70{\%} of temporary narrowing by ACH test and ICS as having < 70{\%} of fixed stenosis on angiography. Patients were divided into two groups: ICS group (n = 764) and non-ICS group (n = 845). To adjust potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. Primary endpoint was the composite of total death, myocardial infraction (MI), de novo percutaneous coronary intervention (PCI), and cerebrovascular accidents (CVA). Secondary endpoint was the incidence of recurrent angina requiring repeat coronary angiography (CAG) at 3 years. Results After PSM analysis, two well-balanced groups (548 pairs, total = 1096) were generated. The baseline clinical characteristics were similar between the two groups. During the ACH test, compared with the non-ICS group, the ICS group had smaller spastic narrowing diameter (0.69 ± 0.35 vs. 0.73 ± 0.37, P = 0.039) and incidence of ST-segment depression (4.0{\%} vs. 0.9{\%}, P = 0.001). The incidence of primary and secondary endpoints was similar between the two groups up to 3 years. Conclusions Although, the ICS group was expected to have more adverse long-term clinical outcomes, it was not associated with the increased incidence of major adverse clinical outcomes compared with the non-ICS group up to 3 years. Longer term follow-up studies are needed.",
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T1 - Three-year follow-up of patients with acetylcholine-induced coronary artery spasm combined with insignificant coronary stenosis

AU - Choi, Byoung Geol

AU - Park, Sung Hun

AU - Rha, Seung-Woon

AU - Ahn, Jihun

AU - Choi, Se Yeon

AU - Byun, Jae Kyeong

AU - Li, Hu

AU - Mashaly, Ahmed

AU - Shim, Min Suk

AU - Kang, Jun Hyuk

AU - Kim, Woohyeun

AU - Choi, Jah Yeon

AU - Park, Eun Jin

AU - Lee, Sunki

AU - Na, Jin Oh

AU - Choi, Cheol Ung

AU - Lim, Hong Euy

AU - Kim, Eung Ju

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background Coronary artery spasm (CAS) and significant coronary stenosis are known to be major causes of myocardial ischemia. However, their association and the impact of insignificant coronary stenosis (ICS) on long-term clinical outcomes of CAS patients are largely unknown. Methods A total of 2797 patients without significant coronary artery disease (CAD) who underwent the acetylcholine (ACH) provocation test between November 2004 and October 2010 were enrolled. Significant CAS was defined as having ≥ 70% of temporary narrowing by ACH test and ICS as having < 70% of fixed stenosis on angiography. Patients were divided into two groups: ICS group (n = 764) and non-ICS group (n = 845). To adjust potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. Primary endpoint was the composite of total death, myocardial infraction (MI), de novo percutaneous coronary intervention (PCI), and cerebrovascular accidents (CVA). Secondary endpoint was the incidence of recurrent angina requiring repeat coronary angiography (CAG) at 3 years. Results After PSM analysis, two well-balanced groups (548 pairs, total = 1096) were generated. The baseline clinical characteristics were similar between the two groups. During the ACH test, compared with the non-ICS group, the ICS group had smaller spastic narrowing diameter (0.69 ± 0.35 vs. 0.73 ± 0.37, P = 0.039) and incidence of ST-segment depression (4.0% vs. 0.9%, P = 0.001). The incidence of primary and secondary endpoints was similar between the two groups up to 3 years. Conclusions Although, the ICS group was expected to have more adverse long-term clinical outcomes, it was not associated with the increased incidence of major adverse clinical outcomes compared with the non-ICS group up to 3 years. Longer term follow-up studies are needed.

AB - Background Coronary artery spasm (CAS) and significant coronary stenosis are known to be major causes of myocardial ischemia. However, their association and the impact of insignificant coronary stenosis (ICS) on long-term clinical outcomes of CAS patients are largely unknown. Methods A total of 2797 patients without significant coronary artery disease (CAD) who underwent the acetylcholine (ACH) provocation test between November 2004 and October 2010 were enrolled. Significant CAS was defined as having ≥ 70% of temporary narrowing by ACH test and ICS as having < 70% of fixed stenosis on angiography. Patients were divided into two groups: ICS group (n = 764) and non-ICS group (n = 845). To adjust potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. Primary endpoint was the composite of total death, myocardial infraction (MI), de novo percutaneous coronary intervention (PCI), and cerebrovascular accidents (CVA). Secondary endpoint was the incidence of recurrent angina requiring repeat coronary angiography (CAG) at 3 years. Results After PSM analysis, two well-balanced groups (548 pairs, total = 1096) were generated. The baseline clinical characteristics were similar between the two groups. During the ACH test, compared with the non-ICS group, the ICS group had smaller spastic narrowing diameter (0.69 ± 0.35 vs. 0.73 ± 0.37, P = 0.039) and incidence of ST-segment depression (4.0% vs. 0.9%, P = 0.001). The incidence of primary and secondary endpoints was similar between the two groups up to 3 years. Conclusions Although, the ICS group was expected to have more adverse long-term clinical outcomes, it was not associated with the increased incidence of major adverse clinical outcomes compared with the non-ICS group up to 3 years. Longer term follow-up studies are needed.

KW - Acetylcholine provocation test

KW - Coronary artery spasm

KW - Coronary artery stenosis

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