Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1

Ha reum Lee; Sun Young Yoon; Ho Bum Kang; Sunyoung Park; Kyung Eun Kim; Young Hoon Cho; Seonghan Kim; Chul woo Kim; Byung Joo Cho; Wang Jae Lee; Sa Ik Bang; Hyunjeong Park; Daeho Cho

doi:10.1016/j.imlet.2009.02.008

Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1

Ha reum Lee, Sun Young Yoon, Ho Bum Kang, Sunyoung Park, Kyung Eun Kim, Young Hoon Cho, Seonghan Kim, Chul woo Kim, Byung Joo Cho, Wang Jae Lee, Sa Ik Bang, Hyunjeong Park, Daeho Cho

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Thymosin beta 4 (Tβ4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, Tβ4's functions in relation to natural killer (NK) cells are still unknown. In this study, we show that synthetic Tβ4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that Tβ4 is a key activator of NK cell cytotoxicity.

Original language	English
Pages (from-to)	72-76
Number of pages	5
Journal	Immunology Letters
Volume	123
Issue number	1
DOIs	https://doi.org/10.1016/j.imlet.2009.02.008
Publication status	Published - 2009 Mar 24
Externally published	Yes

Keywords

ICAM-1
NK cell cytotoxicity
Thymosin beta 4

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.imlet.2009.02.008

Cite this

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title = "Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1",

abstract = "Thymosin beta 4 (Tβ4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, Tβ4's functions in relation to natural killer (NK) cells are still unknown. In this study, we show that synthetic Tβ4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that Tβ4 is a key activator of NK cell cytotoxicity.",

keywords = "ICAM-1, NK cell cytotoxicity, Thymosin beta 4",

author = "Lee, {Ha reum} and Yoon, {Sun Young} and Kang, {Ho Bum} and Sunyoung Park and Kim, {Kyung Eun} and Cho, {Young Hoon} and Seonghan Kim and Kim, {Chul woo} and Cho, {Byung Joo} and Lee, {Wang Jae} and Bang, {Sa Ik} and Hyunjeong Park and Daeho Cho",

note = "Funding Information: This work was supported by the SRC program (Research Center for Women's Diseases, R11-2005-017-04002-0) of Korea Science Engineering Foundation (KOSEF), the Tumor Immunity Medical Research Center (TIMRC) at Seoul National University College of Medicine, and the Korea Research Foundation Grant funded by the Korean Government (KRF-2008-314-E00092).",

year = "2009",

month = mar,

day = "24",

doi = "10.1016/j.imlet.2009.02.008",

language = "English",

volume = "123",

pages = "72--76",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1

AU - Lee, Ha reum

AU - Yoon, Sun Young

AU - Kang, Ho Bum

AU - Park, Sunyoung

AU - Kim, Kyung Eun

AU - Cho, Young Hoon

AU - Kim, Seonghan

AU - Kim, Chul woo

AU - Cho, Byung Joo

AU - Lee, Wang Jae

AU - Bang, Sa Ik

AU - Park, Hyunjeong

AU - Cho, Daeho

N1 - Funding Information: This work was supported by the SRC program (Research Center for Women's Diseases, R11-2005-017-04002-0) of Korea Science Engineering Foundation (KOSEF), the Tumor Immunity Medical Research Center (TIMRC) at Seoul National University College of Medicine, and the Korea Research Foundation Grant funded by the Korean Government (KRF-2008-314-E00092).

PY - 2009/3/24

Y1 - 2009/3/24

N2 - Thymosin beta 4 (Tβ4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, Tβ4's functions in relation to natural killer (NK) cells are still unknown. In this study, we show that synthetic Tβ4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that Tβ4 is a key activator of NK cell cytotoxicity.

AB - Thymosin beta 4 (Tβ4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, Tβ4's functions in relation to natural killer (NK) cells are still unknown. In this study, we show that synthetic Tβ4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that Tβ4 is a key activator of NK cell cytotoxicity.

KW - ICAM-1

KW - NK cell cytotoxicity

KW - Thymosin beta 4

UR - http://www.scopus.com/inward/record.url?scp=64149105500&partnerID=8YFLogxK

U2 - 10.1016/j.imlet.2009.02.008

DO - 10.1016/j.imlet.2009.02.008

M3 - Article

C2 - 19369144

AN - SCOPUS:64149105500

SN - 0165-2478

VL - 123

SP - 72

EP - 76

JO - Immunology Letters

JF - Immunology Letters

IS - 1

ER -

Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1

Abstract

Keywords

ASJC Scopus subject areas

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