Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1

Ha reum Lee, Sun Young Yoon, Ho Bum Kang, Sunyoung Park, Kyung Eun Kim, Young Hoon Cho, Seonghan Kim, Chul woo Kim, Byung Joo Cho, Wang Jae Lee, Sa Ik Bang, Hyunjeong Park, Dae Ho Cho

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12 Citations (Scopus)

Abstract

Thymosin beta 4 (Tβ4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, Tβ4's functions in relation to natural killer (NK) cells are still unknown. In this study, we show that synthetic Tβ4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that Tβ4 is a key activator of NK cell cytotoxicity.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalImmunology Letters
Volume123
Issue number1
DOIs
Publication statusPublished - 2009 Mar 24
Externally publishedYes

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Keywords

  • ICAM-1
  • NK cell cytotoxicity
  • Thymosin beta 4

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Lee, H. R., Yoon, S. Y., Kang, H. B., Park, S., Kim, K. E., Cho, Y. H., Kim, S., Kim, C. W., Cho, B. J., Lee, W. J., Bang, S. I., Park, H., & Cho, D. H. (2009). Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1. Immunology Letters, 123(1), 72-76. https://doi.org/10.1016/j.imlet.2009.02.008