Thyroid follicular neoplasms

Can sonography distinguish between adenomas and carcinomas?

Hyung Suk Seo, Hoon Lee Dong, Hye Park Sung, Sook Min Hye, Dong Gyu Na

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose. The purpose of this study was to determine whether sonography (US) can usefully differentiate thyroid follicular adenoma (FA) and follicular carcinoma (FC). Methods. This retrospective study included 60 pathologically proven FAs and 66 FCs in 123 consecutive patients (17 males and 106 females) with a mean age of 47 ± 13 years, (17-73 years) who underwent thyroid surgery. We analyzed US features of each nodule, including maximum diameter, echogenicity, composition, presence of calcification, margins, and presence of halo. The frequencies of each US feature were compared by using the χ2 test or Fisher's exact test between FAs and FCs. The relative risk of malignancy was evaluated by logistic regression analysis. Results. Isohypoechoic echogenicity, predominantly solid or mixed echotexture, and presence of microcalcifications or rim calcifications were associated with FC (p < 0.05). Logistic regression analysis demonstrated that predominantly solid or mixed echotexture and microcalcifications or rim calcifications were associated with significant increases in relative risk for FC (odds ratio 8.1 and odds ratio 13.5, respectively, p < 0.01). Conclusions. The US features of isohypoechoic echogenicity, predominantly solid or mixed echotexture, and microcalcifications or rim calcifications are more common in FC than in FA.

Original languageEnglish
Pages (from-to)493-500
Number of pages8
JournalJournal of Clinical Ultrasound
Volume37
Issue number9
DOIs
Publication statusPublished - 2009 Nov 1

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Thyroid Neoplasms
Calcinosis
Adenoma
Ultrasonography
Carcinoma
Logistic Models
Odds Ratio
Regression Analysis
Thyroid Gland
Retrospective Studies
Neoplasms

Keywords

  • Follicular adenoma
  • Follicular carcinoma
  • Thyroid
  • Ultrasonography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Thyroid follicular neoplasms : Can sonography distinguish between adenomas and carcinomas? / Seo, Hyung Suk; Dong, Hoon Lee; Sung, Hye Park; Hye, Sook Min; Na, Dong Gyu.

In: Journal of Clinical Ultrasound, Vol. 37, No. 9, 01.11.2009, p. 493-500.

Research output: Contribution to journalArticle

Seo, Hyung Suk ; Dong, Hoon Lee ; Sung, Hye Park ; Hye, Sook Min ; Na, Dong Gyu. / Thyroid follicular neoplasms : Can sonography distinguish between adenomas and carcinomas?. In: Journal of Clinical Ultrasound. 2009 ; Vol. 37, No. 9. pp. 493-500.
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