Time-dependent bioaccumulation of distinct rod-type TiO2 nanoparticles: Comparison by crystalline phase

Eun Jung Park, Gwang Hee Lee, Cheolho Yoon, Min Sung Kang, Soo Nam Kim, Myung Haing Cho, Jae Ho Kim, Dong-Wan Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A complete understanding of the interaction between nanoparticles and biological systems, including nanoparticle uptake and distribution and the biological responses, could guide the design of safer and more effective nanoparticles than those currently available. In this study, we compared the distribution in mice over time of two rod-type titanium dioxide nanoparticles (TiNPs) that feature distinct phases, anatase (ATO) and brookite (BTO). Surface areas of BTO and ATO were estimated to be 102 and 268m2g-1, respectively, and negative charge on the surface of ATO was higher than that of BTO in deionized water. Both TiNPs were rapidly distributed into tissues after injection. At 4weeks after injection, both TiNPs were maximally accumulated in the spleen, followed by the liver, but the total accumulation of ATO in tissues measured in this study was more than that of BTO. Moreover, the cellular antioxidant function was similar although the levels of Ti measured in tissues were distinct between the two TiNPs. Based on these results, we suggest that the fate of TiNPs in the body may differ according to the size and surface charge of the TiNPs even when their shape is the same.

Original languageEnglish
Pages (from-to)1265-1270
Number of pages6
JournalJournal of Applied Toxicology
Volume34
Issue number11
DOIs
Publication statusPublished - 2014 Jan 1

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Bioaccumulation
Nanoparticles
Crystalline materials
Tissue
Injections
titanium dioxide
Deionized water
Biological systems
Surface charge
Liver
Spleen
Antioxidants
Water

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Time-dependent bioaccumulation of distinct rod-type TiO2 nanoparticles : Comparison by crystalline phase. / Park, Eun Jung; Lee, Gwang Hee; Yoon, Cheolho; Kang, Min Sung; Kim, Soo Nam; Cho, Myung Haing; Kim, Jae Ho; Kim, Dong-Wan.

In: Journal of Applied Toxicology, Vol. 34, No. 11, 01.01.2014, p. 1265-1270.

Research output: Contribution to journalArticle

Park, Eun Jung ; Lee, Gwang Hee ; Yoon, Cheolho ; Kang, Min Sung ; Kim, Soo Nam ; Cho, Myung Haing ; Kim, Jae Ho ; Kim, Dong-Wan. / Time-dependent bioaccumulation of distinct rod-type TiO2 nanoparticles : Comparison by crystalline phase. In: Journal of Applied Toxicology. 2014 ; Vol. 34, No. 11. pp. 1265-1270.
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