Tissue- and developmental-stage-specific methylation in the two kidney promoters of the rat γ-glutamyl transpeptidase gene

Ja-Hyun Baik, S. Siegrist, G. Giuili, O. Lahuna, F. Bulle, G. Guellaen

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Abstract

We have investigated, using DNA methylation patterning, the site-specific methylation of promoters I and II of the rat γ-glutamyl transpeptidase gene. This analysis was done in fetal, newborn and adult rat kidney, in which promoters I and II are progressively active during development, as well as in rat liver, which never expresses mRNAs from these two promoters. During kidney development, a progressive demethylation occurs in the promoter I and II region. specially at the level of the most proximal Mspl site of promoter II. A progressive reorganization of the methylated sites within the 5' end of the gene also occurs during liver development.

Original languageEnglish
Pages (from-to)691-694
Number of pages4
JournalBiochemical Journal
Volume287
Issue number3
Publication statusPublished - 1992 Jan 1
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry

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