Tissue- and developmental-stage-specific methylation in the two kidney promoters of the rat γ-glutamyl transpeptidase gene

J. H. Baik, S. Siegrist, G. Giuili, O. Lahuna, F. Bulle, G. Guellaen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We have investigated, using DNA methylation patterning, the site-specific methylation of promoters I and II of the rat γ-glutamyl transpeptidase gene. This analysis was done in fetal, newborn and adult rat kidney, in which promoters I and II are progressively active during development, as well as in rat liver, which never expresses mRNAs from these two promoters. During kidney development, a progressive demethylation occurs in the promoter I and II region. specially at the level of the most proximal Mspl site of promoter II. A progressive reorganization of the methylated sites within the 5' end of the gene also occurs during liver development.

Original languageEnglish
Pages (from-to)691-694
Number of pages4
JournalBiochemical Journal
Volume287
Issue number3
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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