We have investigated, using DNA methylation patterning, the site-specific methylation of promoters I and II of the rat γ-glutamyl transpeptidase gene. This analysis was done in fetal, newborn and adult rat kidney, in which promoters I and II are progressively active during development, as well as in rat liver, which never expresses mRNAs from these two promoters. During kidney development, a progressive demethylation occurs in the promoter I and II region. specially at the level of the most proximal Mspl site of promoter II. A progressive reorganization of the methylated sites within the 5' end of the gene also occurs during liver development.
|Number of pages||4|
|Publication status||Published - 1992 Jan 1|
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