Tissue- and developmental-stage-specific methylation in the two kidney promoters of the rat γ-glutamyl transpeptidase gene

J. H. Baik; S. Siegrist; G. Giuili; O. Lahuna; F. Bulle; G. Guellaen

doi:10.1042/bj2870691

Tissue- and developmental-stage-specific methylation in the two kidney promoters of the rat γ-glutamyl transpeptidase gene

J. H. Baik, S. Siegrist, G. Giuili, O. Lahuna, F. Bulle, G. Guellaen

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We have investigated, using DNA methylation patterning, the site-specific methylation of promoters I and II of the rat γ-glutamyl transpeptidase gene. This analysis was done in fetal, newborn and adult rat kidney, in which promoters I and II are progressively active during development, as well as in rat liver, which never expresses mRNAs from these two promoters. During kidney development, a progressive demethylation occurs in the promoter I and II region. specially at the level of the most proximal Mspl site of promoter II. A progressive reorganization of the methylated sites within the 5' end of the gene also occurs during liver development.

Original language	English
Pages (from-to)	691-694
Number of pages	4
Journal	Biochemical Journal
Volume	287
Issue number	3
DOIs	https://doi.org/10.1042/bj2870691
Publication status	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "We have investigated, using DNA methylation patterning, the site-specific methylation of promoters I and II of the rat γ-glutamyl transpeptidase gene. This analysis was done in fetal, newborn and adult rat kidney, in which promoters I and II are progressively active during development, as well as in rat liver, which never expresses mRNAs from these two promoters. During kidney development, a progressive demethylation occurs in the promoter I and II region. specially at the level of the most proximal Mspl site of promoter II. A progressive reorganization of the methylated sites within the 5' end of the gene also occurs during liver development.",

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AU - Baik, J. H.

AU - Siegrist, S.

AU - Giuili, G.

AU - Lahuna, O.

AU - Bulle, F.

AU - Guellaen, G.

PY - 1992

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AB - We have investigated, using DNA methylation patterning, the site-specific methylation of promoters I and II of the rat γ-glutamyl transpeptidase gene. This analysis was done in fetal, newborn and adult rat kidney, in which promoters I and II are progressively active during development, as well as in rat liver, which never expresses mRNAs from these two promoters. During kidney development, a progressive demethylation occurs in the promoter I and II region. specially at the level of the most proximal Mspl site of promoter II. A progressive reorganization of the methylated sites within the 5' end of the gene also occurs during liver development.

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ER -

Tissue- and developmental-stage-specific methylation in the two kidney promoters of the rat γ-glutamyl transpeptidase gene

Abstract

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