Tissue distribution following 28 day repeated oral administration of aluminum-based nanoparticles with different properties and the in vitro toxicity

Eun Jung Park, Gwang Hee Lee, Cheolho Yoon, Uiseok Jeong, Younghun Kim, Jaerak Chang, Dong-Wan Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The tissue distribution and toxicity of nanoparticles (NPs) depend on their physical and chemical properties both in the manufactured condition and within the biological system. We characterized three types of commercially available aluminum-based NPs (Al-NPs), two rod-type aluminum oxide NPs (Al2O3, AlONPs), with different aspect ratios (short [S]- and long [L]-AlONPs), and spherical aluminum cerium oxide NPs (AlCeO3, AlCeONPs). The surface area was in order of the S-AlONPs > L-AlONPs > AlCeONPs. Very importantly, we found that AlCeONPs is Al2O3-coated CeO2 NPs, but not AlCeO3 NPs, and that the Al level in AlCeONPs is approximately 20% of those in S- and L-AlONPs. All three types of Al-NPs were slightly ionized in gastric fluid and rapidly particlized in the intestinal fluid. There were no significant differences in the body weight gain following 28 days of repeated oral administration of the three different types of Al-NPs. All Al-NPs elevated Al level in the heart, spleen, kidney and blood at 24 hours after the final dose, accompanied by the altered tissue level of redox reaction-related trace elements. Subsequently, in four types of cells derived from the organs which Al-NPs are accumulated, H9C2 (heart), HEK-293 (kidney), splenocytes and RAW264.7 (blood), S-AlONPs showed a very low uptake level and did not exert significant cytotoxicity. Meanwhile, cytotoxicity and uptake level were the most remarkable in cells treated with AlCeONPs. In conclusion, we suggest that the physicochemical properties of NPs should be examined in detail before the release into the market to prevent unexpected adverse health effects.

Original languageEnglish
Pages (from-to)1408-1419
Number of pages12
JournalJournal of Applied Toxicology
Volume37
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1

Fingerprint

Tissue Distribution
Aluminum
Nanoparticles
Oral Administration
Toxicity
Tissue
Aluminum Oxide
Cytotoxicity
Blood
Kidney
Fluids
In Vitro Techniques
Redox reactions
Trace Elements
Biological systems
Chemical properties
Weight Gain
Oxidation-Reduction
Aspect ratio
Stomach

Keywords

  • aluminum oxide nanoparticles
  • cerium oxide nanoparticles
  • physicochemical properties
  • tissue distribution
  • toxicity

ASJC Scopus subject areas

  • Toxicology

Cite this

Tissue distribution following 28 day repeated oral administration of aluminum-based nanoparticles with different properties and the in vitro toxicity. / Park, Eun Jung; Lee, Gwang Hee; Yoon, Cheolho; Jeong, Uiseok; Kim, Younghun; Chang, Jaerak; Kim, Dong-Wan.

In: Journal of Applied Toxicology, Vol. 37, No. 12, 01.12.2017, p. 1408-1419.

Research output: Contribution to journalArticle

Park, Eun Jung ; Lee, Gwang Hee ; Yoon, Cheolho ; Jeong, Uiseok ; Kim, Younghun ; Chang, Jaerak ; Kim, Dong-Wan. / Tissue distribution following 28 day repeated oral administration of aluminum-based nanoparticles with different properties and the in vitro toxicity. In: Journal of Applied Toxicology. 2017 ; Vol. 37, No. 12. pp. 1408-1419.
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AB - The tissue distribution and toxicity of nanoparticles (NPs) depend on their physical and chemical properties both in the manufactured condition and within the biological system. We characterized three types of commercially available aluminum-based NPs (Al-NPs), two rod-type aluminum oxide NPs (Al2O3, AlONPs), with different aspect ratios (short [S]- and long [L]-AlONPs), and spherical aluminum cerium oxide NPs (AlCeO3, AlCeONPs). The surface area was in order of the S-AlONPs > L-AlONPs > AlCeONPs. Very importantly, we found that AlCeONPs is Al2O3-coated CeO2 NPs, but not AlCeO3 NPs, and that the Al level in AlCeONPs is approximately 20% of those in S- and L-AlONPs. All three types of Al-NPs were slightly ionized in gastric fluid and rapidly particlized in the intestinal fluid. There were no significant differences in the body weight gain following 28 days of repeated oral administration of the three different types of Al-NPs. All Al-NPs elevated Al level in the heart, spleen, kidney and blood at 24 hours after the final dose, accompanied by the altered tissue level of redox reaction-related trace elements. Subsequently, in four types of cells derived from the organs which Al-NPs are accumulated, H9C2 (heart), HEK-293 (kidney), splenocytes and RAW264.7 (blood), S-AlONPs showed a very low uptake level and did not exert significant cytotoxicity. Meanwhile, cytotoxicity and uptake level were the most remarkable in cells treated with AlCeONPs. In conclusion, we suggest that the physicochemical properties of NPs should be examined in detail before the release into the market to prevent unexpected adverse health effects.

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