Abstract
Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.
| Original language | English |
|---|---|
| Pages (from-to) | 661-665 |
| Number of pages | 5 |
| Journal | Infection and Immunity |
| Volume | 73 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 Jan 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. / Lee, Marie Mei; Yoon, Bongjune; Osiewicz, Keith; Preston, Michael; Bundy, Brian; Van Heeckeren, Anna M.; Werb, Zena; Soloway, Paul D.
In: Infection and Immunity, Vol. 73, No. 1, 01.01.2005, p. 661-665.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tissue inhibitor of metalloproteinase 1 regulates resistance to infection
AU - Lee, Marie Mei
AU - Yoon, Bongjune
AU - Osiewicz, Keith
AU - Preston, Michael
AU - Bundy, Brian
AU - Van Heeckeren, Anna M.
AU - Werb, Zena
AU - Soloway, Paul D.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.
AB - Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.
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UR - http://www.scopus.com/inward/citedby.url?scp=11144262076&partnerID=8YFLogxK
U2 - 10.1128/IAI.73.1.661-665.2005
DO - 10.1128/IAI.73.1.661-665.2005
M3 - Article
VL - 73
SP - 661
EP - 665
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 1
ER -