Abstract
Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.
| Original language | English |
|---|---|
| Pages (from-to) | 661-665 |
| Number of pages | 5 |
| Journal | Infection and Immunity |
| Volume | 73 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 Jan |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases
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Cite this
Lee, M. M., Yoon, B. J., Osiewicz, K., Preston, M., Bundy, B., Van Heeckeren, A. M., Werb, Z., & Soloway, P. D. (2005). Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infection and Immunity, 73(1), 661-665. https://doi.org/10.1128/IAI.73.1.661-665.2005