Tissue inhibitor of metalloproteinase 1 regulates resistance to infection

Marie Mei Lee; Bong June Yoon; Keith Osiewicz; Michael Preston; Brian Bundy; Anna M. Van Heeckeren; Zena Werb; Paul D. Soloway

doi:10.1128/IAI.73.1.661-665.2005

Tissue inhibitor of metalloproteinase 1 regulates resistance to infection

Marie Mei Lee, Bong June Yoon, Keith Osiewicz, Michael Preston, Brian Bundy, Anna M. Van Heeckeren, Zena Werb, Paul D. Soloway

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.

Original language	English
Pages (from-to)	661-665
Number of pages	5
Journal	Infection and Immunity
Volume	73
Issue number	1
DOIs	https://doi.org/10.1128/IAI.73.1.661-665.2005
Publication status	Published - 2005 Jan
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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abstract = "Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.",

author = "Lee, {Marie Mei} and Yoon, {Bong June} and Keith Osiewicz and Michael Preston and Brian Bundy and {Van Heeckeren}, {Anna M.} and Zena Werb and Soloway, {Paul D.}",

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AU - Lee, Marie Mei

AU - Yoon, Bong June

AU - Osiewicz, Keith

AU - Preston, Michael

AU - Bundy, Brian

AU - Van Heeckeren, Anna M.

AU - Werb, Zena

AU - Soloway, Paul D.

PY - 2005/1

Y1 - 2005/1

N2 - Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.

AB - Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.

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JO - Infection and Immunity

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SN - 0019-9567

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Tissue inhibitor of metalloproteinase 1 regulates resistance to infection

Abstract

ASJC Scopus subject areas

UN SDGs

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