Tissue inhibitor of metalloproteinase 1 regulates resistance to infection

Marie Mei Lee, Bongjune Yoon, Keith Osiewicz, Michael Preston, Brian Bundy, Anna M. Van Heeckeren, Zena Werb, Paul D. Soloway

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.

Original languageEnglish
Pages (from-to)661-665
Number of pages5
JournalInfection and Immunity
Volume73
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1
Externally publishedYes

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Tissue Inhibitor of Metalloproteinase-1
Infection
Matrix Metalloproteinase 12
Matrix Metalloproteinase 7
Genetic Suppression
Matrix Metalloproteinase 3
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Cornea
Pseudomonas aeruginosa
Lung

ASJC Scopus subject areas

  • Immunology

Cite this

Lee, M. M., Yoon, B., Osiewicz, K., Preston, M., Bundy, B., Van Heeckeren, A. M., ... Soloway, P. D. (2005). Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infection and Immunity, 73(1), 661-665. https://doi.org/10.1128/IAI.73.1.661-665.2005

Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. / Lee, Marie Mei; Yoon, Bongjune; Osiewicz, Keith; Preston, Michael; Bundy, Brian; Van Heeckeren, Anna M.; Werb, Zena; Soloway, Paul D.

In: Infection and Immunity, Vol. 73, No. 1, 01.01.2005, p. 661-665.

Research output: Contribution to journalArticle

Lee, MM, Yoon, B, Osiewicz, K, Preston, M, Bundy, B, Van Heeckeren, AM, Werb, Z & Soloway, PD 2005, 'Tissue inhibitor of metalloproteinase 1 regulates resistance to infection', Infection and Immunity, vol. 73, no. 1, pp. 661-665. https://doi.org/10.1128/IAI.73.1.661-665.2005
Lee, Marie Mei ; Yoon, Bongjune ; Osiewicz, Keith ; Preston, Michael ; Bundy, Brian ; Van Heeckeren, Anna M. ; Werb, Zena ; Soloway, Paul D. / Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. In: Infection and Immunity. 2005 ; Vol. 73, No. 1. pp. 661-665.
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