TY - JOUR
T1 - Tissue inhibitor of metalloproteinase 1 regulates resistance to infection
AU - Lee, Marie Mei
AU - Yoon, Bong June
AU - Osiewicz, Keith
AU - Preston, Michael
AU - Bundy, Brian
AU - Van Heeckeren, Anna M.
AU - Werb, Zena
AU - Soloway, Paul D.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/1
Y1 - 2005/1
N2 - Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.
AB - Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.
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U2 - 10.1128/IAI.73.1.661-665.2005
DO - 10.1128/IAI.73.1.661-665.2005
M3 - Article
C2 - 15618213
AN - SCOPUS:11144262076
VL - 73
SP - 661
EP - 665
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 1
ER -