Tissue Segmentation Using Sparse Non-negative Matrix Factorization of Spherical Mean Diffusion MRI Data

Peng Sun, Ye Wu, Geng Chen, Jun Wu, Dinggang Shen, Pew Thian Yap

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we present a method based on sparse non-negative matrix factorization (NMF) for brain tissue segmentation using diffusion MRI (DMRI) data. Unlike existing NMF-based approaches, in our method NMF is applied to the spherical mean data, computed on a per-shell basis, instead of the original diffusion-weighted images. This is motivated by the fact that the spherical mean is independent of the fiber orientation distribution and is only dependent on tissue microstructure. Applying NMF to the spherical mean data will hence allow tissue signal separation based solely on the microstructural properties, unconfounded by factors such as fiber dispersion and crossing. We show results explaining why applying NMF directly on the diffusion-weighted images fails and why our method is able to yield the expected outcome, producing tissue segmentation with greater accuracy.

Original languageEnglish
Title of host publicationMathematics and Visualization
EditorsChantal M.W. Tax, Lipeng Ning, Elisenda Bonet-Carne, Francesco Grussu, Farshid Sepehrband
PublisherSpringer Heidelberg
Pages69-76
Number of pages8
Edition226249
ISBN (Print)9783030058302
DOIs
Publication statusPublished - 2019
Externally publishedYes
EventInternational Workshop on Computational Diffusion MRI, CDMRI 2018 held with International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018 - Granada, Spain
Duration: 2018 Sep 202018 Sep 20

Publication series

NameMathematics and Visualization
Number226249
ISSN (Print)1612-3786
ISSN (Electronic)2197-666X

Conference

ConferenceInternational Workshop on Computational Diffusion MRI, CDMRI 2018 held with International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018
CountrySpain
CityGranada
Period18/9/2018/9/20

Keywords

  • Diffusion MRI
  • Sparse NMF
  • Spherical mean
  • Tissue segmentation

ASJC Scopus subject areas

  • Modelling and Simulation
  • Geometry and Topology
  • Computer Graphics and Computer-Aided Design
  • Applied Mathematics

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