Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma

Gyu Young Hur, Sung Ho Kim, Sang Myun Park, Young Min Ye, Cheol Woo Kim, An Soo Jang, Choon Sik Park, Chein Soo Hong, Hae Sim Park

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: This study was conducted to evaluate whether tissue transglutaminase (tTG) may be involved in airway inflammation of toluene diisocyanate-induced occupational asthma (TDI-OA). Methods: We enrolled 93 patients with TDI-OA, 177 asymptomatic exposed subjects, 43 patients with allergic asthma, and 70 unexposed normal controls. The prevalence of serum immunoglobulin G (IgG) to tTG in the TDI-OA group (20.2%) was significantly higher than that in the three other groups (P<0.001). Results: TDI-OA patients with serum IgG to tTG had significantly lower methacholine PC 20 values (P<0.02) and significantly higher prevalence of specific immunoglobulin E to vapor type TDI-human serum albumin conjugate (P<0.01; r 2=0.411, P<0.05). TDI exposure could increase tTG activity via reactive oxygen species (ROS) production, which was found to cross-link with cytokeratin 19 on immunoblot analysis. Conclusion: Therefore, TDI exposure may activate tTG via ROS-mediated mechanism in the airway epithelium leading to persistent airway inflammation in TDI-OA patients.

Original languageEnglish
Pages (from-to)786-794
Number of pages9
JournalJournal of Clinical Immunology
Volume29
Issue number6
DOIs
Publication statusPublished - 2009 Nov 1

Keywords

  • Occupational asthma
  • Specific immunoglobulin E
  • Toluene diisocyanate
  • Transglutaminase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma'. Together they form a unique fingerprint.

  • Cite this

    Hur, G. Y., Kim, S. H., Park, S. M., Ye, Y. M., Kim, C. W., Jang, A. S., Park, C. S., Hong, C. S., & Park, H. S. (2009). Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma. Journal of Clinical Immunology, 29(6), 786-794. https://doi.org/10.1007/s10875-009-9314-8