TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: A meta-analysis

Young Ho Lee, Gwan Gyu Song

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    The purpose of this study was to examine whether tumor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted examining the association between TNF-α -308 A/G and -238 A/G polymorphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorphisms were included in this meta-analysis. The meta-analysis revealed no association between the TNF-α -308 A allele and glaucoma [odds ratio (OR) = 1.403, 95% confidence interval (CI) = 0.784-2.513, P = 0.254]. Subgroup analysis by disease type revealed no association between the TNF-α -308 A allele and glaucoma. The meta-analysis revealed no significant association between the TNF-α -238 A allele and glaucoma (OR = 1.120, 95%CI = 0.708-1.773, P = 0.628). This meta-analysis showed no association between the A alleles of the TNF-α -308 A/G or -238 A/G polymorphisms and glaucoma.

    Original languageEnglish
    Pages (from-to)4966-4977
    Number of pages12
    JournalGenetics and Molecular Research
    Volume14
    Issue number2
    DOIs
    Publication statusPublished - 2015 May 11

    Keywords

    • Glaucoma
    • Meta-analysis
    • Polymorphism
    • TNF-α

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics

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