TNF-alpha -308G>A polymorphism is associated with suicide attempts in major depressive disorder

Yong Ku Kim, Jin Pyo Hong, Jung A. Hwang, Heon-Jeong Lee, Ho-Kyoung Yoon, Bun Hee Lee, Han Yong Jung, Sang Woo Hahn, Kyoung Sae Na

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background Despite the substantial role of the cytokine network in depression and suicide, few studies have investigated the role of genetic polymorphisms of pro- and anti-inflammatory cytokines in suicide in major depressive disorder (MDD). The aim of this study was to investigate whether tumor necrosis factor-alpha (TNF-alpha) -308G>A, interferon-gamma (IFN-gamma) +874A>T, and interleukin-10 (IL-10) -1082A>G are associated with increased risk for suicide attempts in MDD. Methods Among patients with MDD, 204 patients who had attempted suicide and 97 control patients who had not attempted suicide were recruited. A chi-square test was used to identify a possible risk genotype or allele type for suicide. A subsequent multivariate logistic regression analysis was conducted to investigate the influence of a risk genotype or allele type adjusted for other environmental factors. The lethality of the suicide attempt was also tested between genotype and allele types among suicidal patients with MDD. Results The GG genotype of the TNF-alpha -308G>A polymorphism was found to significantly increase risk for suicide attempt (adjusted OR=2.630, 95% CI=1.206 to 5.734). IFN-gamma +874A>T and IL-10 -1082A>G were not associated with risk for suicide. Lethality of the suicide attempt was not associated with any of the three cytokine genotypes or allele types. Limitations Limitations include a relatively small sample size and a cross-sectional design. Conclusions TNF-alpha -308G>A polymorphism is an independent risk factor for suicide attempts in MDD. Future studies should clarify the neural mechanisms by which the GG genotype of TNF-alpha -308G>A influences suicide in MDD.

Original languageEnglish
Pages (from-to)668-672
Number of pages5
JournalJournal of Affective Disorders
Volume150
Issue number2
DOIs
Publication statusPublished - 2013 Sep 5

Fingerprint

Major Depressive Disorder
Suicide
Tumor Necrosis Factor-alpha
Genotype
Alleles
Attempted Suicide
Cytokines
Interleukin-10
Interferon-gamma
Genetic Polymorphisms
Chi-Square Distribution
Sample Size
Anti-Inflammatory Agents
Logistic Models
Regression Analysis
Depression

Keywords

  • Depression
  • Interferon-gamma
  • Interleukin-10
  • Suicide
  • Tumor necrosis factor-alpha

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

TNF-alpha -308G>A polymorphism is associated with suicide attempts in major depressive disorder. / Kim, Yong Ku; Hong, Jin Pyo; Hwang, Jung A.; Lee, Heon-Jeong; Yoon, Ho-Kyoung; Lee, Bun Hee; Jung, Han Yong; Hahn, Sang Woo; Na, Kyoung Sae.

In: Journal of Affective Disorders, Vol. 150, No. 2, 05.09.2013, p. 668-672.

Research output: Contribution to journalArticle

Kim, Yong Ku ; Hong, Jin Pyo ; Hwang, Jung A. ; Lee, Heon-Jeong ; Yoon, Ho-Kyoung ; Lee, Bun Hee ; Jung, Han Yong ; Hahn, Sang Woo ; Na, Kyoung Sae. / TNF-alpha -308G>A polymorphism is associated with suicide attempts in major depressive disorder. In: Journal of Affective Disorders. 2013 ; Vol. 150, No. 2. pp. 668-672.
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abstract = "Background Despite the substantial role of the cytokine network in depression and suicide, few studies have investigated the role of genetic polymorphisms of pro- and anti-inflammatory cytokines in suicide in major depressive disorder (MDD). The aim of this study was to investigate whether tumor necrosis factor-alpha (TNF-alpha) -308G>A, interferon-gamma (IFN-gamma) +874A>T, and interleukin-10 (IL-10) -1082A>G are associated with increased risk for suicide attempts in MDD. Methods Among patients with MDD, 204 patients who had attempted suicide and 97 control patients who had not attempted suicide were recruited. A chi-square test was used to identify a possible risk genotype or allele type for suicide. A subsequent multivariate logistic regression analysis was conducted to investigate the influence of a risk genotype or allele type adjusted for other environmental factors. The lethality of the suicide attempt was also tested between genotype and allele types among suicidal patients with MDD. Results The GG genotype of the TNF-alpha -308G>A polymorphism was found to significantly increase risk for suicide attempt (adjusted OR=2.630, 95{\%} CI=1.206 to 5.734). IFN-gamma +874A>T and IL-10 -1082A>G were not associated with risk for suicide. Lethality of the suicide attempt was not associated with any of the three cytokine genotypes or allele types. Limitations Limitations include a relatively small sample size and a cross-sectional design. Conclusions TNF-alpha -308G>A polymorphism is an independent risk factor for suicide attempts in MDD. Future studies should clarify the neural mechanisms by which the GG genotype of TNF-alpha -308G>A influences suicide in MDD.",
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T1 - TNF-alpha -308G>A polymorphism is associated with suicide attempts in major depressive disorder

AU - Kim, Yong Ku

AU - Hong, Jin Pyo

AU - Hwang, Jung A.

AU - Lee, Heon-Jeong

AU - Yoon, Ho-Kyoung

AU - Lee, Bun Hee

AU - Jung, Han Yong

AU - Hahn, Sang Woo

AU - Na, Kyoung Sae

PY - 2013/9/5

Y1 - 2013/9/5

N2 - Background Despite the substantial role of the cytokine network in depression and suicide, few studies have investigated the role of genetic polymorphisms of pro- and anti-inflammatory cytokines in suicide in major depressive disorder (MDD). The aim of this study was to investigate whether tumor necrosis factor-alpha (TNF-alpha) -308G>A, interferon-gamma (IFN-gamma) +874A>T, and interleukin-10 (IL-10) -1082A>G are associated with increased risk for suicide attempts in MDD. Methods Among patients with MDD, 204 patients who had attempted suicide and 97 control patients who had not attempted suicide were recruited. A chi-square test was used to identify a possible risk genotype or allele type for suicide. A subsequent multivariate logistic regression analysis was conducted to investigate the influence of a risk genotype or allele type adjusted for other environmental factors. The lethality of the suicide attempt was also tested between genotype and allele types among suicidal patients with MDD. Results The GG genotype of the TNF-alpha -308G>A polymorphism was found to significantly increase risk for suicide attempt (adjusted OR=2.630, 95% CI=1.206 to 5.734). IFN-gamma +874A>T and IL-10 -1082A>G were not associated with risk for suicide. Lethality of the suicide attempt was not associated with any of the three cytokine genotypes or allele types. Limitations Limitations include a relatively small sample size and a cross-sectional design. Conclusions TNF-alpha -308G>A polymorphism is an independent risk factor for suicide attempts in MDD. Future studies should clarify the neural mechanisms by which the GG genotype of TNF-alpha -308G>A influences suicide in MDD.

AB - Background Despite the substantial role of the cytokine network in depression and suicide, few studies have investigated the role of genetic polymorphisms of pro- and anti-inflammatory cytokines in suicide in major depressive disorder (MDD). The aim of this study was to investigate whether tumor necrosis factor-alpha (TNF-alpha) -308G>A, interferon-gamma (IFN-gamma) +874A>T, and interleukin-10 (IL-10) -1082A>G are associated with increased risk for suicide attempts in MDD. Methods Among patients with MDD, 204 patients who had attempted suicide and 97 control patients who had not attempted suicide were recruited. A chi-square test was used to identify a possible risk genotype or allele type for suicide. A subsequent multivariate logistic regression analysis was conducted to investigate the influence of a risk genotype or allele type adjusted for other environmental factors. The lethality of the suicide attempt was also tested between genotype and allele types among suicidal patients with MDD. Results The GG genotype of the TNF-alpha -308G>A polymorphism was found to significantly increase risk for suicide attempt (adjusted OR=2.630, 95% CI=1.206 to 5.734). IFN-gamma +874A>T and IL-10 -1082A>G were not associated with risk for suicide. Lethality of the suicide attempt was not associated with any of the three cytokine genotypes or allele types. Limitations Limitations include a relatively small sample size and a cross-sectional design. Conclusions TNF-alpha -308G>A polymorphism is an independent risk factor for suicide attempts in MDD. Future studies should clarify the neural mechanisms by which the GG genotype of TNF-alpha -308G>A influences suicide in MDD.

KW - Depression

KW - Interferon-gamma

KW - Interleukin-10

KW - Suicide

KW - Tumor necrosis factor-alpha

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DO - 10.1016/j.jad.2013.03.019

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