Topical administration of cyclosporin A in a solid lipid nanoparticle formulation

Sung Tae Kim, Dong Jin Jang, Jong Hyo Kim, Joo Yeon Park, Ji Soo Lim, So Yeon Lee, Kyung Mi Lee, Soo Jeong Lim, Chong Kook Kim

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Cyclosporin A (CsA)-loaded solid lipid nanoparticles (SLN) were developed for improved skin penetration. CsA-loaded SLN, prepared using a hot homogenization method, were nano-sized (about 73 nm) with a slightly negative surface charge (about -16 mV) and stable under physiological conditions regardless of CsA incorporation. In vitro permeation studies using murine skin mounted in the Franztype vertical diffusion assembly revealed that the skin permeation efficiency of CsA-loaded SLN was 2-fold higher than that of CsA-oil mixture in viable skin. Furthermore, topically administered CsAloaded SLN relieved symptoms of atopic dermatitis (AD) in an in vivo murine model of AD by decreasing the T helper (Th) 2 cell-related cytokines interleukin (IL)-4 and -5. These results suggest that SLN are effective drug carriers for topical delivery and that CsA-loaded SLN can be therapeutically applied in allergy-related skin disorders.

Original languageEnglish
Pages (from-to)510-514
Number of pages5
JournalPharmazie
Volume64
Issue number8
DOIs
Publication statusPublished - 2009 Aug 1

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Kim, S. T., Jang, D. J., Kim, J. H., Park, J. Y., Lim, J. S., Lee, S. Y., Lee, K. M., Lim, S. J., & Kim, C. K. (2009). Topical administration of cyclosporin A in a solid lipid nanoparticle formulation. Pharmazie, 64(8), 510-514. https://doi.org/10.1691/ph.2009.8373