Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population

Xiaoyan Sun, Yang-Hyun Kim, Trong Nhat Phan, Beom Seok Yang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Burn scar contracture that follows the healing of deep dermal burns causes severe deformation and functional impairment. However, its current therapeutic interventions are limited with unsatisfactory outcomes. When we treated deep second-degree burns in rat skin with activin-like kinase 5 (ALK5) inhibitor A-83-01, it reduced wound contraction and enhanced the area of re-epithelialization so that the overall time for wound closing was not altered. In addition, it reduced myofibroblast population in the dermis of burn scar with a diminished deposition of its biomarker proteins such as α-SMA and collagen. Treatment of rat dermal fibroblast with A-83-01 inhibited transforming growth factor-β1 (TGF-β1)- dependent induction of α-SMA and collagen type I. Taken together, these results suggest that topical application of ALK5 inhibitor A-83-01 could be effective in preventing the contraction of burn wound without delaying the wound closure by virtue of its inhibitory activity against the TGF-β-induced increase of myofibroblast population.

Original languageEnglish
Pages (from-to)1805-1812
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume78
Issue number11
DOIs
Publication statusPublished - 2014 Jan 1

Keywords

  • A-83-01
  • ALK5 inhibitor
  • Burn wound contraction
  • Myofibroblast
  • Signaling
  • TGF-β

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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