Abstract
The stereoselective synthesis of fimsbactin A, a siderophore of the human pathogen Acinetobacter baumannii, was established. Based on this synthetic route, various fimsbactin stereoisomeric analogues were generated and tested for their iron delivery activity for A. baumannii. This investigation revealed that the fimsbactin uptake machinery in this bacterium was indeed highly stereoselective in substrate recognition.
Original language | English |
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Pages (from-to) | 2806-2810 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 22 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2020 Apr 3 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry