Total Syntheses of Fimsbactin A and B and Their Stereoisomers to Probe the Stereoselectivity of the Fimsbactin Uptake Machinery in Acinetobacter baumannii

Soojeung Kim, Haeun Lee, Woon Young Song, Hak Joong Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The stereoselective synthesis of fimsbactin A, a siderophore of the human pathogen Acinetobacter baumannii, was established. Based on this synthetic route, various fimsbactin stereoisomeric analogues were generated and tested for their iron delivery activity for A. baumannii. This investigation revealed that the fimsbactin uptake machinery in this bacterium was indeed highly stereoselective in substrate recognition.

Original languageEnglish
Pages (from-to)2806-2810
Number of pages5
JournalOrganic Letters
Volume22
Issue number7
DOIs
Publication statusPublished - 2020 Apr 3

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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