Toward exosome-based neuronal diagnostic devices

Yong Kyoung Yoo, Junwoo Lee, Hyungsuk Kim, Kyo Seon Hwang, Dae Sung Yoon, Jeong Hoon Lee

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Targeting exosome for liquid biopsy has gained significant attention for its diagnostic and therapeutic potential. For detecting neuronal disease diagnosis such as Alzheimer's disease (AD), the main technique for identifying AD still relies on positron-emission tomography (PET) imaging to detect the presence of amyloid-β (Aβ). While the detection of Aβ in cerebrospinal fluid has also been suggested as a marker for AD, the lack of quantitative measurements has compromised existing assays. In cerebrospinal fluid, in addition to Aβ, T-Tau, and P-Tau, alpha-synuclein has been considered a biomarker of neurodegeneration. This review suggests that and explains how the exosome can be used as a neuronal diagnostic component. To this end, we summarize current progress in exosome preparation/isolation and quantification techniques and comment on the outlooks for neuronal exosome-based diagnostic techniques.

Original languageEnglish
Article number634
JournalMicromachines
Volume9
Issue number12
DOIs
Publication statusPublished - 2018 Nov 29

Keywords

  • Alzheimer's disease
  • Diagnostics
  • Exosome
  • Parkinson's disease

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Yoo, Y. K., Lee, J., Kim, H., Hwang, K. S., Yoon, D. S., & Lee, J. H. (2018). Toward exosome-based neuronal diagnostic devices. Micromachines, 9(12), [634]. https://doi.org/10.3390/mi9120634