Towards the application of human defensins as antivirals

Mee Sook Park, Jin Il Kim, Ilseob Lee, Sehee Park, Joon Yong Bae, Man-Seong Park

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express α- and β-defensins, which are known for their antiviral and antibacterial activities. This review describes the application of human defensins. We discuss the extant experimental results, limited though they are, to consider the potential applicability of human defensins as antiviral agents. Given their antiviral effects, we propose that basic research be conducted on human defensins that focuses on RNA viruses, such as human immunodeficiency virus (HIV), influenza A virus (IAV), respiratory syncytial virus (RSV), and dengue virus (DENV), which are considered serious human pathogens but have posed huge challenges for vaccine development for different reasons. Concerning the prophylactic and therapeutic applications of defensins, we then discuss the applicability of human defensins as antivirals that has been demonstrated in reports using animal models. Finally, we discuss the potential adjuvant-like activity of human defensins and propose an exploration of the ‘defensin vaccine’ concept to prime the body with a controlled supply of human defensins. In sum, we suggest a conceptual framework to achieve the practical application of human defensins to combat viral infections.

Original languageEnglish
Pages (from-to)242-254
Number of pages13
JournalBiomolecules and Therapeutics
Volume26
Issue number3
DOIs
Publication statusPublished - 2018 May 1

Fingerprint

Defensins
Antiviral Agents
Viruses
Vaccines
Dengue Virus
Respiratory Syncytial Viruses
RNA Viruses
Influenza A virus
Pathogens
Virus Diseases
Innate Immunity
Human Activities
Animals
Animal Models

Keywords

  • Adjuvant
  • Antiviral
  • Defensin
  • Prophylactic
  • Therapeutic
  • Virus

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

Towards the application of human defensins as antivirals. / Park, Mee Sook; Kim, Jin Il; Lee, Ilseob; Park, Sehee; Bae, Joon Yong; Park, Man-Seong.

In: Biomolecules and Therapeutics, Vol. 26, No. 3, 01.05.2018, p. 242-254.

Research output: Contribution to journalReview article

Park, Mee Sook ; Kim, Jin Il ; Lee, Ilseob ; Park, Sehee ; Bae, Joon Yong ; Park, Man-Seong. / Towards the application of human defensins as antivirals. In: Biomolecules and Therapeutics. 2018 ; Vol. 26, No. 3. pp. 242-254.
@article{a4556756da524b94acaf5ac7eb4d9037,
title = "Towards the application of human defensins as antivirals",
abstract = "Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express α- and β-defensins, which are known for their antiviral and antibacterial activities. This review describes the application of human defensins. We discuss the extant experimental results, limited though they are, to consider the potential applicability of human defensins as antiviral agents. Given their antiviral effects, we propose that basic research be conducted on human defensins that focuses on RNA viruses, such as human immunodeficiency virus (HIV), influenza A virus (IAV), respiratory syncytial virus (RSV), and dengue virus (DENV), which are considered serious human pathogens but have posed huge challenges for vaccine development for different reasons. Concerning the prophylactic and therapeutic applications of defensins, we then discuss the applicability of human defensins as antivirals that has been demonstrated in reports using animal models. Finally, we discuss the potential adjuvant-like activity of human defensins and propose an exploration of the ‘defensin vaccine’ concept to prime the body with a controlled supply of human defensins. In sum, we suggest a conceptual framework to achieve the practical application of human defensins to combat viral infections.",
keywords = "Adjuvant, Antiviral, Defensin, Prophylactic, Therapeutic, Virus",
author = "Park, {Mee Sook} and Kim, {Jin Il} and Ilseob Lee and Sehee Park and Bae, {Joon Yong} and Man-Seong Park",
year = "2018",
month = "5",
day = "1",
doi = "10.4062/biomolther.2017.172",
language = "English",
volume = "26",
pages = "242--254",
journal = "Biomolecules and Therapeutics",
issn = "1976-9148",
publisher = "Korean Society of Applied Pharmacology",
number = "3",

}

TY - JOUR

T1 - Towards the application of human defensins as antivirals

AU - Park, Mee Sook

AU - Kim, Jin Il

AU - Lee, Ilseob

AU - Park, Sehee

AU - Bae, Joon Yong

AU - Park, Man-Seong

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express α- and β-defensins, which are known for their antiviral and antibacterial activities. This review describes the application of human defensins. We discuss the extant experimental results, limited though they are, to consider the potential applicability of human defensins as antiviral agents. Given their antiviral effects, we propose that basic research be conducted on human defensins that focuses on RNA viruses, such as human immunodeficiency virus (HIV), influenza A virus (IAV), respiratory syncytial virus (RSV), and dengue virus (DENV), which are considered serious human pathogens but have posed huge challenges for vaccine development for different reasons. Concerning the prophylactic and therapeutic applications of defensins, we then discuss the applicability of human defensins as antivirals that has been demonstrated in reports using animal models. Finally, we discuss the potential adjuvant-like activity of human defensins and propose an exploration of the ‘defensin vaccine’ concept to prime the body with a controlled supply of human defensins. In sum, we suggest a conceptual framework to achieve the practical application of human defensins to combat viral infections.

AB - Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express α- and β-defensins, which are known for their antiviral and antibacterial activities. This review describes the application of human defensins. We discuss the extant experimental results, limited though they are, to consider the potential applicability of human defensins as antiviral agents. Given their antiviral effects, we propose that basic research be conducted on human defensins that focuses on RNA viruses, such as human immunodeficiency virus (HIV), influenza A virus (IAV), respiratory syncytial virus (RSV), and dengue virus (DENV), which are considered serious human pathogens but have posed huge challenges for vaccine development for different reasons. Concerning the prophylactic and therapeutic applications of defensins, we then discuss the applicability of human defensins as antivirals that has been demonstrated in reports using animal models. Finally, we discuss the potential adjuvant-like activity of human defensins and propose an exploration of the ‘defensin vaccine’ concept to prime the body with a controlled supply of human defensins. In sum, we suggest a conceptual framework to achieve the practical application of human defensins to combat viral infections.

KW - Adjuvant

KW - Antiviral

KW - Defensin

KW - Prophylactic

KW - Therapeutic

KW - Virus

UR - http://www.scopus.com/inward/record.url?scp=85046746536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046746536&partnerID=8YFLogxK

U2 - 10.4062/biomolther.2017.172

DO - 10.4062/biomolther.2017.172

M3 - Review article

AN - SCOPUS:85046746536

VL - 26

SP - 242

EP - 254

JO - Biomolecules and Therapeutics

JF - Biomolecules and Therapeutics

SN - 1976-9148

IS - 3

ER -