Toxicity Evaluation by Single and Repeated Administration of Yeast Hydrolysate DNF-10

Yejin Ahn, Singeun Kim, Hyung Joo Suh, Eun Young Jung

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed at investigating the acute and subacute oral toxicity of yeast hydrolysate (DNF-10) in Sprague-Dawley rats. To determine the acute toxicity of DNF-10, it was orally administered to rats at a dose of 5,000 mg/kg. Furthermore, to determine subacute toxicity of DNF-10, it was orally administered to female and male rats at a dose of 1,000 mg/kg for 90 days. In the acute toxicity test, the experimental group did not show changes in body and organ weights compared to the corresponding weights in the control group. When compared to female controls, the DNF-10-treated female rats showed decreased red blood cell counts, haemoglobin, and total bilirubin levels; however, the parameters remained within the normal range. In the subacute toxicity test, DNF-10 administration significantly reduced body weight among male rats, which appears attributable to the anti-obesity effect of the compound. In the experimental groups, significant differences in some haematological parameters were considered as non-toxic because the results were within the normal range. These results suggest that DNF-10 is safe and non-toxic at single doses (5,000 mg/kg) and repeated doses (1,000 mg/kg).

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalPreventive Nutrition and Food Science
Volume26
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • Acute toxicity
  • Saccharomyces cerevisiae
  • Subacute toxicity
  • Yeast hydrolysate

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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