Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats

Yu Ri Kim, Seung Young Lee, Eun Jeong Lee, Sung Ha Park, Nak Won Seong, Heung Sik Seo, Sung Sup Shin, Seon Ju Kim, Eun Ho Meang, Myeong Kyu Park, Min Seok Kim, Cheol Su Kim, Soo Ki Kim, Sang Wook Son, Young Rok Seo, Boo Hyon Kang, Beom Seok Han, Seong Soo A An, Beom Jun Lee, Meyoung-Kon Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This study was undertaken to investigate the potential toxicity and establish the no observed adverse effect level (NOAEL) and target organ(s) of negatively charged colloidal silica particles of different sizes, ie, SiO2 EN20(-) (20 nm) or SiO2 EN100(-) (100 nm), administered by gavage in Sprague-Dawley rats. After verification of the physicochemical properties of the SiO2 particles to be tested, a preliminary dose range-finding study and 90-day repeated dose study were conducted according to the Organisation for Economic Cooperation and Development test guideline. Based on the results of the 14-day dose range-finding study, a high dose was determined to be 2,000 mg/kg, and middle and low doses were set at 1,000 and 500 mg/kg, respectively. In the 90-day toxicity study, there were no animal deaths in relation to administration of SiO2 particles of either size. In addition, no treatment-related clinical changes or histopathological findings were observed in any of the experimental groups. Moreover, no difference in toxic effects from chronic exposure to SiO2 EN20(-) (20 nm) or SiO2 EN100(-) (100 nm) was observed. The results of this study indicate that the NOAEL for SiO2 EN20(-) and SiO2 EN100(-) would most likely be 2,000 mg/kg, and no target organ was identified in rats of either sex.

Original languageEnglish
Pages (from-to)67-78
Number of pages12
JournalInternational Journal of Nanomedicine
Volume9
DOIs
Publication statusPublished - 2014 Dec 15

Keywords

  • 90-day oral dose toxicity
  • No observed adverse effect level
  • Particle size
  • Silica nanoparticles

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Organic Chemistry
  • Drug Discovery

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  • Cite this

    Kim, Y. R., Lee, S. Y., Lee, E. J., Park, S. H., Seong, N. W., Seo, H. S., Shin, S. S., Kim, S. J., Meang, E. H., Park, M. K., Kim, M. S., Kim, C. S., Kim, S. K., Son, S. W., Seo, Y. R., Kang, B. H., Han, B. S., An, S. S. A., Lee, B. J., & Kim, M-K. (2014). Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats. International Journal of Nanomedicine, 9, 67-78. https://doi.org/10.2147/IJN.S57925