Toxicogenomic analysis of the pulmonary toxic effects of hexanal in F344 rat

Yoon Cho, Jung hee Lim, Mi Kyung Song, Seung Chan Jeong, Kyuhong Lee, Yongju Heo, Tae Sung Kim, Jae Chun Ryu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hexanal is a major component of indoor air pollutants and is a kind of aldehydes; it has adverse effects on human health. We performed an in vivo inhalation study and transcriptomic analysis to determine the mode of toxic actions in response to hexanal. Fischer 344 rats of both sexes were exposed by inhalation to hexanal aerosol for 4 h day-1, 5 days week-1 for 4 weeks at 0, 600, 1000, and 1500 ppm. Throughout our microarray-based genome-wide expression analysis, we identified 56 differentially expressed genes in three doses of hexanal; among these genes, 11 genes showed dose-dependent expression patterns (10 downregulated and 1 upregulated, 1.5-fold, p

Original languageEnglish
JournalEnvironmental Toxicology
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Toxicogenetics
Poisons
Inbred F344 Rats
Rats
Genes
Lung
gene
Inhalation
indoor air
aldehyde
Toxic Actions
Air Pollutants
Microarrays
genome
Aerosols
Aldehydes
aerosol
fold
Down-Regulation
Health

Keywords

  • Aldehyde
  • Environmental genomics
  • Hexanal
  • Indoor air pollutant
  • Respiratory system

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Management, Monitoring, Policy and Law

Cite this

Cho, Y., Lim, J. H., Song, M. K., Jeong, S. C., Lee, K., Heo, Y., ... Ryu, J. C. (Accepted/In press). Toxicogenomic analysis of the pulmonary toxic effects of hexanal in F344 rat. Environmental Toxicology. https://doi.org/10.1002/tox.22242

Toxicogenomic analysis of the pulmonary toxic effects of hexanal in F344 rat. / Cho, Yoon; Lim, Jung hee; Song, Mi Kyung; Jeong, Seung Chan; Lee, Kyuhong; Heo, Yongju; Kim, Tae Sung; Ryu, Jae Chun.

In: Environmental Toxicology, 2016.

Research output: Contribution to journalArticle

Cho, Yoon ; Lim, Jung hee ; Song, Mi Kyung ; Jeong, Seung Chan ; Lee, Kyuhong ; Heo, Yongju ; Kim, Tae Sung ; Ryu, Jae Chun. / Toxicogenomic analysis of the pulmonary toxic effects of hexanal in F344 rat. In: Environmental Toxicology. 2016.
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