Toxicogenomic analysis of the pulmonary toxic effects of hexanal in F344 rat

Yoon Cho, Jung hee Lim, Mi Kyung Song, Seung Chan Jeong, Kyuhong Lee, Yongju Heo, Tae Sung Kim, Jae Chun Ryu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hexanal is a major component of indoor air pollutants and is a kind of aldehydes; it has adverse effects on human health. We performed an in vivo inhalation study and transcriptomic analysis to determine the mode of toxic actions in response to hexanal. Fischer 344 rats of both sexes were exposed by inhalation to hexanal aerosol for 4 h day-1, 5 days week-1 for 4 weeks at 0, 600, 1000, and 1500 ppm. Throughout our microarray-based genome-wide expression analysis, we identified 56 differentially expressed genes in three doses of hexanal; among these genes, 11 genes showed dose-dependent expression patterns (10 downregulated and 1 upregulated, 1.5-fold, p

Original languageEnglish
JournalEnvironmental Toxicology
DOIs
Publication statusAccepted/In press - 2016

Keywords

  • Aldehyde
  • Environmental genomics
  • Hexanal
  • Indoor air pollutant
  • Respiratory system

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Management, Monitoring, Policy and Law

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    Cho, Y., Lim, J. H., Song, M. K., Jeong, S. C., Lee, K., Heo, Y., Kim, T. S., & Ryu, J. C. (Accepted/In press). Toxicogenomic analysis of the pulmonary toxic effects of hexanal in F344 rat. Environmental Toxicology. https://doi.org/10.1002/tox.22242