Toxicological evaluation of fucoidan from Undaria pinnatifida in vitro and in vivo

Hyuck J. Chung, Jungae Jeun, Soung J. Houng, Hee J. Jun, Dong Keon Kweon, Sung-Joon Lee

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The potential toxicity of fucoidan from Undaria pinnatifida was investigated in vitro and in vivo. By the Ames test, fucoidan showed no mutagenicity up to 500 μL/plate, and inhibited the mutagenicity induced by 4-nitro-quinoline-1-oxide, by up to 71%, compared with controls. In the bone marrow micronucleus test, fucoidan, at all levels tested, did not change the micronucleated polychromatic erythrocyte percentage ratio in mouse bone marrow cells. As an acute in vivo toxicity test, fucoidan from 0 to 2000 mg/kg body weight per day was administered orally to Sprague-Dawley rats for 28 days. No significant toxicological change was induced by fucoidan treatment up to 1000 mg/kg body weight per day in biochemical analyses, hematological analyses, necropsy and liver histopathology. The plasma ALT level was slightly, but significantly, increased in male rats at 2000 mg/kg/ day. The consumption of fucoidan from Undaria pinnatifida, up to 1000 mg/kg body weight per day, may be safe in rodents, with no sign of toxicity after up to 28 days of daily administration.

Original languageEnglish
Pages (from-to)1078-1083
Number of pages6
JournalPhytotherapy Research
Volume24
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1

Fingerprint

Undaria
Toxicology
Body Weight
4-Nitroquinoline-1-oxide
Toxicity Tests
Micronucleus Tests
Bone Marrow Cells
Sprague Dawley Rats
In Vitro Techniques
fucoidan
Rodentia
Erythrocytes
Bone Marrow
Liver

Keywords

  • 28-Day oral toxicity test
  • Ames test
  • Bone marrow micronucleus test
  • Fucoidan
  • Undaria pinnatifida

ASJC Scopus subject areas

  • Pharmacology

Cite this

Toxicological evaluation of fucoidan from Undaria pinnatifida in vitro and in vivo. / Chung, Hyuck J.; Jeun, Jungae; Houng, Soung J.; Jun, Hee J.; Kweon, Dong Keon; Lee, Sung-Joon.

In: Phytotherapy Research, Vol. 24, No. 7, 01.07.2010, p. 1078-1083.

Research output: Contribution to journalArticle

Chung, Hyuck J. ; Jeun, Jungae ; Houng, Soung J. ; Jun, Hee J. ; Kweon, Dong Keon ; Lee, Sung-Joon. / Toxicological evaluation of fucoidan from Undaria pinnatifida in vitro and in vivo. In: Phytotherapy Research. 2010 ; Vol. 24, No. 7. pp. 1078-1083.
@article{d0958866dccf4e698bebb08f85062cb8,
title = "Toxicological evaluation of fucoidan from Undaria pinnatifida in vitro and in vivo",
abstract = "The potential toxicity of fucoidan from Undaria pinnatifida was investigated in vitro and in vivo. By the Ames test, fucoidan showed no mutagenicity up to 500 μL/plate, and inhibited the mutagenicity induced by 4-nitro-quinoline-1-oxide, by up to 71{\%}, compared with controls. In the bone marrow micronucleus test, fucoidan, at all levels tested, did not change the micronucleated polychromatic erythrocyte percentage ratio in mouse bone marrow cells. As an acute in vivo toxicity test, fucoidan from 0 to 2000 mg/kg body weight per day was administered orally to Sprague-Dawley rats for 28 days. No significant toxicological change was induced by fucoidan treatment up to 1000 mg/kg body weight per day in biochemical analyses, hematological analyses, necropsy and liver histopathology. The plasma ALT level was slightly, but significantly, increased in male rats at 2000 mg/kg/ day. The consumption of fucoidan from Undaria pinnatifida, up to 1000 mg/kg body weight per day, may be safe in rodents, with no sign of toxicity after up to 28 days of daily administration.",
keywords = "28-Day oral toxicity test, Ames test, Bone marrow micronucleus test, Fucoidan, Undaria pinnatifida",
author = "Chung, {Hyuck J.} and Jungae Jeun and Houng, {Soung J.} and Jun, {Hee J.} and Kweon, {Dong Keon} and Sung-Joon Lee",
year = "2010",
month = "7",
day = "1",
doi = "10.1002/ptr.3138",
language = "English",
volume = "24",
pages = "1078--1083",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "John Wiley and Sons Ltd",
number = "7",

}

TY - JOUR

T1 - Toxicological evaluation of fucoidan from Undaria pinnatifida in vitro and in vivo

AU - Chung, Hyuck J.

AU - Jeun, Jungae

AU - Houng, Soung J.

AU - Jun, Hee J.

AU - Kweon, Dong Keon

AU - Lee, Sung-Joon

PY - 2010/7/1

Y1 - 2010/7/1

N2 - The potential toxicity of fucoidan from Undaria pinnatifida was investigated in vitro and in vivo. By the Ames test, fucoidan showed no mutagenicity up to 500 μL/plate, and inhibited the mutagenicity induced by 4-nitro-quinoline-1-oxide, by up to 71%, compared with controls. In the bone marrow micronucleus test, fucoidan, at all levels tested, did not change the micronucleated polychromatic erythrocyte percentage ratio in mouse bone marrow cells. As an acute in vivo toxicity test, fucoidan from 0 to 2000 mg/kg body weight per day was administered orally to Sprague-Dawley rats for 28 days. No significant toxicological change was induced by fucoidan treatment up to 1000 mg/kg body weight per day in biochemical analyses, hematological analyses, necropsy and liver histopathology. The plasma ALT level was slightly, but significantly, increased in male rats at 2000 mg/kg/ day. The consumption of fucoidan from Undaria pinnatifida, up to 1000 mg/kg body weight per day, may be safe in rodents, with no sign of toxicity after up to 28 days of daily administration.

AB - The potential toxicity of fucoidan from Undaria pinnatifida was investigated in vitro and in vivo. By the Ames test, fucoidan showed no mutagenicity up to 500 μL/plate, and inhibited the mutagenicity induced by 4-nitro-quinoline-1-oxide, by up to 71%, compared with controls. In the bone marrow micronucleus test, fucoidan, at all levels tested, did not change the micronucleated polychromatic erythrocyte percentage ratio in mouse bone marrow cells. As an acute in vivo toxicity test, fucoidan from 0 to 2000 mg/kg body weight per day was administered orally to Sprague-Dawley rats for 28 days. No significant toxicological change was induced by fucoidan treatment up to 1000 mg/kg body weight per day in biochemical analyses, hematological analyses, necropsy and liver histopathology. The plasma ALT level was slightly, but significantly, increased in male rats at 2000 mg/kg/ day. The consumption of fucoidan from Undaria pinnatifida, up to 1000 mg/kg body weight per day, may be safe in rodents, with no sign of toxicity after up to 28 days of daily administration.

KW - 28-Day oral toxicity test

KW - Ames test

KW - Bone marrow micronucleus test

KW - Fucoidan

KW - Undaria pinnatifida

UR - http://www.scopus.com/inward/record.url?scp=77954513678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954513678&partnerID=8YFLogxK

U2 - 10.1002/ptr.3138

DO - 10.1002/ptr.3138

M3 - Article

C2 - 20578121

AN - SCOPUS:77954513678

VL - 24

SP - 1078

EP - 1083

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 7

ER -