Tracheal reconstruction with asymmetrically porous polycaprolactone/ pluronic F127 membranes

Seong Keun Kwon, Jae Jun Song, Chang Gun Cho, Seok Won Park, Jin Rae Kim, Se Heang Oh, Jin Ho Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background Congenital and acquired tracheal stenosis continues to be challenging problems. The purpose of this study was to evaluate the efficacy of an asymmetrically porous membrane (APM) to induce tracheal reconstruction by inhibition of granulation tissue growth into the tracheal lumen whereas minimizing graft failure. Methods The APM was fabricated with polycaprolactone (PCL) and pluronic F127 to have nano-size pores at top side, whereas the bottom side had micro-size pores. Fifteen rabbits underwent tracheal defect, which was then reconstructed with the APM. Rabbits were euthanized 1, 4, and 12 weeks postoperatively, and endoscopic, histologic, and radiologic evaluations were conducted. Results Endoscopy did not reveal granulation ingrowth into tracheal lumen. APM was well incorporated into the surrounding tissue on histologic evaluation. CT scans showed well maintained airways. Conclusion Off-the-shelf use of APM for tracheal reconstruction seems to be a promising strategy in the treatment of tracheal defects.

Original languageEnglish
Pages (from-to)643-651
Number of pages9
JournalHead and Neck
Volume36
Issue number5
DOIs
Publication statusPublished - 2014 May
Externally publishedYes

Keywords

  • asymmetrically porous membrane
  • polycaprolactone
  • prosthesis
  • reconstruction
  • trachea

ASJC Scopus subject areas

  • Otorhinolaryngology

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  • Cite this

    Kwon, S. K., Song, J. J., Cho, C. G., Park, S. W., Kim, J. R., Oh, S. H., & Lee, J. H. (2014). Tracheal reconstruction with asymmetrically porous polycaprolactone/ pluronic F127 membranes. Head and Neck, 36(5), 643-651. https://doi.org/10.1002/hed.23343