Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment

Na Yeon Jung, Cheol E. Han, Hee Jin Kim, Sang Wook Yoo, Hee Jong Kim, Eun Joo Kim, Duk L. Na, Samuel N. Lockhart, William J. Jagust, Jun Kyung Seong, Sang Won Seo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The white matter tract-specific correlates of neuropsychological deficits are not fully established in patients with subcortical vascular cognitive impairment (SVCI), where white matter tract damage may be a critical factor in cognitive impairment. The purpose of this study is to investigate the tract-specific correlates of neuropsychological deficits in SVCI patients using tract-specific statistical analysis (TSSA). We prospectively recruited 114 SVCI patients, and 55 age-, gender-, and education-matched individuals with normal cognition (NC). All participants underwent diffusion weighted imaging and neuropsychological testing. We classified tractography results into fourteen major fiber tracts and analyzed group comparison and correlation with cognitive impairments. Relative to NC subjects, SVCI patients showed decreased fractional anisotropy values in bilateral anterior-thalamic radiation, cingulum, superior-longitudinal fasciculus, uncinate fasciculus, corticospinal tract, and left inferior-longitudinal fasciculus. Focal disruptions in specific tracts were associated with specific cognitive impairments. Our findings suggest that disconnection of specific white matter tracts, especially those neighboring and providing connections between gray matter regions important to certain cognitive functions, may contribute to specific cognitive impairments in SVCI.

Original languageEnglish
Pages (from-to)1125-1135
Number of pages11
JournalJournal of Alzheimer's Disease
Volume50
Issue number4
DOIs
Publication statusPublished - 2016 Feb 22

Fingerprint

Blood Vessels
Cognition
Cognitive Dysfunction
Pyramidal Tracts
Anisotropy
Radiation
Education
White Matter

Keywords

  • Diffusion-tensor imaging
  • neuropsychological correlation
  • subcortical vascular cognitive impairment
  • tractspecific statistical analysis
  • white matter connectivity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment. / Jung, Na Yeon; Han, Cheol E.; Kim, Hee Jin; Yoo, Sang Wook; Kim, Hee Jong; Kim, Eun Joo; Na, Duk L.; Lockhart, Samuel N.; Jagust, William J.; Seong, Jun Kyung; Seo, Sang Won.

In: Journal of Alzheimer's Disease, Vol. 50, No. 4, 22.02.2016, p. 1125-1135.

Research output: Contribution to journalArticle

Jung, NY, Han, CE, Kim, HJ, Yoo, SW, Kim, HJ, Kim, EJ, Na, DL, Lockhart, SN, Jagust, WJ, Seong, JK & Seo, SW 2016, 'Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment', Journal of Alzheimer's Disease, vol. 50, no. 4, pp. 1125-1135. https://doi.org/10.3233/JAD-150841
Jung, Na Yeon ; Han, Cheol E. ; Kim, Hee Jin ; Yoo, Sang Wook ; Kim, Hee Jong ; Kim, Eun Joo ; Na, Duk L. ; Lockhart, Samuel N. ; Jagust, William J. ; Seong, Jun Kyung ; Seo, Sang Won. / Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment. In: Journal of Alzheimer's Disease. 2016 ; Vol. 50, No. 4. pp. 1125-1135.
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