Abstract
Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether trans-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and trans-anethole reduced both blood pressure and vascular tone. These findings are the first to show that trans-anethole can prevent hypertension, suggesting that trans-anethole may be useful as a prophylactic antihypertensive agent.
| Original language | English |
|---|---|
| Pages (from-to) | 249-253 |
| Number of pages | 5 |
| Journal | Biomedicine and Pharmacotherapy |
| Volume | 102 |
| DOIs | |
| Publication status | Published - 2018 Jun 1 |
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Keywords
- Hypertension
- Nicotine
- Restraint
- Stress
- Trans-anethole
ASJC Scopus subject areas
- Pharmacology
Cite this
Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats. / Seo, Eunhye; Kang, Purum; Seol, Geun Hee.
In: Biomedicine and Pharmacotherapy, Vol. 102, 01.06.2018, p. 249-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats
AU - Seo, Eunhye
AU - Kang, Purum
AU - Seol, Geun Hee
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether trans-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and trans-anethole reduced both blood pressure and vascular tone. These findings are the first to show that trans-anethole can prevent hypertension, suggesting that trans-anethole may be useful as a prophylactic antihypertensive agent.
AB - Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether trans-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and trans-anethole reduced both blood pressure and vascular tone. These findings are the first to show that trans-anethole can prevent hypertension, suggesting that trans-anethole may be useful as a prophylactic antihypertensive agent.
KW - Hypertension
KW - Nicotine
KW - Restraint
KW - Stress
KW - Trans-anethole
UR - http://www.scopus.com/inward/record.url?scp=85044101747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044101747&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2018.03.081
DO - 10.1016/j.biopha.2018.03.081
M3 - Article
C2 - 29567537
AN - SCOPUS:85044101747
VL - 102
SP - 249
EP - 253
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
SN - 0753-3322
ER -