Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats

Eunhye Seo, Purum Kang, Geun Hee Seol

Research output: Contribution to journalArticle

Abstract

Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether trans-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and trans-anethole reduced both blood pressure and vascular tone. These findings are the first to show that trans-anethole can prevent hypertension, suggesting that trans-anethole may be useful as a prophylactic antihypertensive agent.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalBiomedicine and Pharmacotherapy
Volume102
DOIs
Publication statusPublished - 2018 Jun 1

Fingerprint

Nicotine
Hypertension
Nifedipine
Exercise
Blood Vessels
Smoking
Blood Pressure
Aptitude
anethole
Causality
Antihypertensive Agents

Keywords

  • Hypertension
  • Nicotine
  • Restraint
  • Stress
  • Trans-anethole

ASJC Scopus subject areas

  • Pharmacology

Cite this

Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats. / Seo, Eunhye; Kang, Purum; Seol, Geun Hee.

In: Biomedicine and Pharmacotherapy, Vol. 102, 01.06.2018, p. 249-253.

Research output: Contribution to journalArticle

@article{81bbb5d2bd8e4b25a6d37fc1504ca224,
title = "Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats",
abstract = "Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether trans-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and trans-anethole reduced both blood pressure and vascular tone. These findings are the first to show that trans-anethole can prevent hypertension, suggesting that trans-anethole may be useful as a prophylactic antihypertensive agent.",
keywords = "Hypertension, Nicotine, Restraint, Stress, Trans-anethole",
author = "Eunhye Seo and Purum Kang and Seol, {Geun Hee}",
year = "2018",
month = "6",
day = "1",
doi = "10.1016/j.biopha.2018.03.081",
language = "English",
volume = "102",
pages = "249--253",
journal = "Biomedicine and Pharmacotherapy",
issn = "0753-3322",
publisher = "Elsevier Masson",

}

TY - JOUR

T1 - Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats

AU - Seo, Eunhye

AU - Kang, Purum

AU - Seol, Geun Hee

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether trans-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and trans-anethole reduced both blood pressure and vascular tone. These findings are the first to show that trans-anethole can prevent hypertension, suggesting that trans-anethole may be useful as a prophylactic antihypertensive agent.

AB - Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether trans-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and trans-anethole reduced both blood pressure and vascular tone. These findings are the first to show that trans-anethole can prevent hypertension, suggesting that trans-anethole may be useful as a prophylactic antihypertensive agent.

KW - Hypertension

KW - Nicotine

KW - Restraint

KW - Stress

KW - Trans-anethole

UR - http://www.scopus.com/inward/record.url?scp=85044101747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044101747&partnerID=8YFLogxK

U2 - 10.1016/j.biopha.2018.03.081

DO - 10.1016/j.biopha.2018.03.081

M3 - Article

C2 - 29567537

AN - SCOPUS:85044101747

VL - 102

SP - 249

EP - 253

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

SN - 0753-3322

ER -