Trans-anethole protects cortical neuronal cells against oxygen-glucose deprivation/reoxygenation

Sangwoo Ryu, Geun Hee Seol, Hyeon Park, In Young Choi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Trans-anethole has been studied on pharmacological properties such as anti-inflammation, anti-oxidative stress, antifungal and anticancer. However, to date, the anti-ischemic effects of trans-anethole have not been assessed. Therefore, we investigated the neuroprotection of trans-anethole against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced cortical neuronal cell injury, an in vitro model of ischemia. The abilities of trans-anethole to block excitotoxicity, oxidative stress and mitochondrial dysfunction were evaluated in OGD/R-induced neurons. Trans-anethole significantly ameliorated OGD/R-induced neuronal cell injury by attenuating the intracellular calcium overload via the activation of NMDA receptors. Trans-anethole also inhibited OGD/R-induced reactive oxygen species overproduction, which may be derived from the scavenging activity in peroxyl radicals, assessed in an oxygen radical absorbance capacity assay. Furthermore, trans-anethole was shown to attenuate the depolarization of mitochondrial transmembrane. These results indicated that the neuroprotective effect of trans-anethole on OGD/R-induced neuronal injury might be due to its ability to inhibit excitotoxicity, oxidative stress and mitochondrial dysfunction. Considering these multiple pathways causing ischemic neuronal damage, the multi-functional effect of trans-anethole suggested that it may be effective in treating ischemic stroke.

Original languageEnglish
Pages (from-to)1541-1547
Number of pages7
JournalNeurological Sciences
Volume35
Issue number10
DOIs
Publication statusPublished - 2014 Jan 1

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Oxygen
Glucose
Oxidative Stress
Wounds and Injuries
anethole
Neuroprotective Agents
N-Methyl-D-Aspartate Receptors
Reactive Oxygen Species
Ischemia
Stroke
Pharmacology
Inflammation
Calcium
Neurons

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

Cite this

Trans-anethole protects cortical neuronal cells against oxygen-glucose deprivation/reoxygenation. / Ryu, Sangwoo; Seol, Geun Hee; Park, Hyeon; Choi, In Young.

In: Neurological Sciences, Vol. 35, No. 10, 01.01.2014, p. 1541-1547.

Research output: Contribution to journalArticle

Ryu, Sangwoo ; Seol, Geun Hee ; Park, Hyeon ; Choi, In Young. / Trans-anethole protects cortical neuronal cells against oxygen-glucose deprivation/reoxygenation. In: Neurological Sciences. 2014 ; Vol. 35, No. 10. pp. 1541-1547.
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