Trans-cranial doppler and peripheral sensory threshold tests for carbon disulfide poisoning

Eun Il Lee, Hun Jong Chung, Soonduck Kim, Jong Tae Park, Dong Geun Sul, Myung Hyun Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Trans-cranial doppler (TCD) and sensory threshold (vibration, pain and discrimination) tests, which are safe and inexpensive techniques, were applied to detect cerebral vasoreactivity or neuropathic changes between carbon disulfide (CS 2) poisoning cases and two control groups respectively. The cases were 31 male CS 2 poisoning workers, and the first control group for the TCD test consisted of eight healthy men, and the second group for the threshold test were 21 healthy male workers. In the TCD test, the blood flow velocity in both middle cerebral arteries and the CO 2 content of expired air were measured to evaluate CO 2 reactivity. The vibration and pain perception threshold were measured on both the 2nd and 5th fingers. The CS 2 poisoning cases showed higher rates of abnormal CO 2 reactivity above the cut-off value than healthy controls (80.081.8% vs 0%). Among the threshold tests, the proportions of abnormal pain threshold of both the 2nd and 5th fingers were higher in poisoning cases than in the controls (77.8%-88.9% vs 11.1-33.3%) among over 45 yr old subjects. CO 2 reactivity and pain threshold test showed the possibility to detect changes in cerebral vessels and the sensory threshold in CS 2 exposure cases, but there should be further study to apply these tests to workers exposed to CS 2 before the development of CS 2 poisoning, with large number of control subjects.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalJournal of Occupational Health
Volume43
Issue number6
Publication statusPublished - 2001 Dec 1

Fingerprint

Sensory Thresholds
Carbon Disulfide
Poisoning
Carbon Monoxide
Pain Threshold
Vibration
Fingers
Control Groups
Pain Perception
Blood Flow Velocity
Middle Cerebral Artery
Flow velocity
Blood
Air
Pain

Keywords

  • Carbon disulfide
  • Sensory threshold
  • Trans-cranial doppler songography

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology

Cite this

Trans-cranial doppler and peripheral sensory threshold tests for carbon disulfide poisoning. / Lee, Eun Il; Chung, Hun Jong; Kim, Soonduck; Park, Jong Tae; Sul, Dong Geun; Kim, Myung Hyun.

In: Journal of Occupational Health, Vol. 43, No. 6, 01.12.2001, p. 307-313.

Research output: Contribution to journalArticle

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