Transcranial focused ultrasound stimulation of human primary visual cortex

Wonhye Lee, Hyun Chul Kim, Yujin Jung, Yong An Chung, In Uk Song, Jong-Hwan Lee, Seung Schik Yoo

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Transcranial focused ultrasound (FUS) is making progress as a new non-invasive mode of regional brain stimulation. Current evidence of FUS-mediated neurostimulation for humans has been limited to the observation of subjective sensory manifestations and electrophysiological responses, thus warranting the identification of stimulated brain regions. Here, we report FUS sonication of the primary visual cortex (V1) in humans, resulting in elicited activation not only from the sonicated brain area, but also from the network of regions involved in visual and higher-order cognitive processes (as revealed by simultaneous acquisition of blood-oxygenation-level-dependent functional magnetic resonance imaging). Accompanying phosphene perception was also reported. The electroencephalo graphic (EEG) responses showed distinct peaks associated with the stimulation. None of the participants showed any adverse effects from the sonication based on neuroimaging and neurological examinations. Retrospective numerical simulation of the acoustic profile showed the presence of individual variability in terms of the location and intensity of the acoustic focus. With exquisite spatial selectivity and capability for depth penetration, FUS may confer a unique utility in providing non-invasive stimulation of region-specific brain circuits for neuroscientific and therapeutic applications.

Original languageEnglish
Article number34026
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016 Sep 23

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Visual Cortex
Sonication
Brain
Acoustics
Phosphenes
Neurologic Examination
Neuroimaging
Magnetic Resonance Imaging
Observation
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Lee, W., Kim, H. C., Jung, Y., Chung, Y. A., Song, I. U., Lee, J-H., & Yoo, S. S. (2016). Transcranial focused ultrasound stimulation of human primary visual cortex. Scientific Reports, 6, [34026]. https://doi.org/10.1038/srep34026

Transcranial focused ultrasound stimulation of human primary visual cortex. / Lee, Wonhye; Kim, Hyun Chul; Jung, Yujin; Chung, Yong An; Song, In Uk; Lee, Jong-Hwan; Yoo, Seung Schik.

In: Scientific Reports, Vol. 6, 34026, 23.09.2016.

Research output: Contribution to journalArticle

Lee, Wonhye ; Kim, Hyun Chul ; Jung, Yujin ; Chung, Yong An ; Song, In Uk ; Lee, Jong-Hwan ; Yoo, Seung Schik. / Transcranial focused ultrasound stimulation of human primary visual cortex. In: Scientific Reports. 2016 ; Vol. 6.
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