Transcriptional alteration of p53 related processes as a key factor for skeletal muscle characteristics in Sus scrofa

Seung Soo Kim, Jung Rok Kim, Jin Kyoo Moon, Bong Hwan Choi, Tae Hun Kim, Kwan Suk Kim, Jong Joo Kim, Cheol-Koo Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The pig could be a useful model to characterize molecular aspects determining several delicate phenotypes because they have been bred for those characteristics. The Korean native pig (KNP) is a regional breed in Korea that was characterized by relatively high intramuscular fat content and reddish meat color compared to other western breeds such as Yorkshire (YS). YS grew faster and contained more lean muscle than KNP. We compared the KNP to Yorksire to find molecular clues determining muscle characteristics. The comparison of skeletal gene expression profiles between these two breeds showed molecular differences in muscle. We found 82 differentially expressed genes (DEGs) defined by fold change (more than 1.5 fold difference) and statistical significance (within 5% of false discovery rate). Functional analyses of these DEGs indicated up-regulation of most genes involved in cell cycle arrest, down-regulation of most genes involved in cellular differentiation and its inhibition, down-regulation of most genes encoding component of muscular-structural system, and up-regulation of most genes involved in diverse metabolism in KNP. Especially, DEGs in above-mentioned categories included a large number of genes encoding proteins directly or indirectly involved in p53 pathway. Our results indicated a possible role of p53 to determine muscle characteristics between these two breeds.

Original languageEnglish
Pages (from-to)565-573
Number of pages9
JournalMolecules and Cells
Volume28
Issue number6
DOIs
Publication statusPublished - 2009 Dec 1

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Keywords

  • Differentially expressed gene
  • Korean native pig
  • P53
  • Skeletal muscle
  • Sus scrofa

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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