Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice

Eun Hee Ahn, Dae Won Kim, Hye Won Kang, Min Jae Shin, Moo Ho Won, Joon Kim, Dong Joon Kim, Oh Shin Kwon, Tae Cheon Kang, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Choi

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34 Citations (Scopus)

Abstract

This study investigated the preventive effect of ribosomal protein S3 (rpS3) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. A cell permeable expression vector PEP-1-rpS3 was constructed. Topical application of the vector markedly inhibited TPA-induced expression levels of cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines. Application of PEP-1-rpS3 also resulted in a significant reduction in the activation of nuclear factor-kappa B (NF-. kB) and mitogen-activated protein kinase (MAPK) in TPA-treated ears. These results indicate that PEP-1-rpS3 inhibits inflammatory response cytokines and enzymes by blocking NF-. kB and MAPK, prompting the suggestion that PEP-1-rpS3 can be used as a therapeutic agent against skin inflammation.

Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalToxicology
Volume276
Issue number3
DOIs
Publication statusPublished - 2010 Oct 29

Keywords

  • Inflammation
  • MAPK
  • PEP-1-rpS3
  • TPA

ASJC Scopus subject areas

  • Toxicology

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    Ahn, E. H., Kim, D. W., Kang, H. W., Shin, M. J., Won, M. H., Kim, J., Kim, D. J., Kwon, O. S., Kang, T. C., Han, K. H., Park, J., Eum, W. S., & Choi, S. Y. (2010). Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Toxicology, 276(3), 192-197. https://doi.org/10.1016/j.tox.2010.08.004