Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice

Eun Hee Ahn, Dae Won Kim, Hye Won Kang, Min Jae Shin, Moo Ho Won, Joon Kim, Dong Joon Kim, Oh Shin Kwon, Tae Cheon Kang, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Choi

Research output: Contribution to journalArticle

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Abstract

This study investigated the preventive effect of ribosomal protein S3 (rpS3) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. A cell permeable expression vector PEP-1-rpS3 was constructed. Topical application of the vector markedly inhibited TPA-induced expression levels of cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines. Application of PEP-1-rpS3 also resulted in a significant reduction in the activation of nuclear factor-kappa B (NF-. kB) and mitogen-activated protein kinase (MAPK) in TPA-treated ears. These results indicate that PEP-1-rpS3 inhibits inflammatory response cytokines and enzymes by blocking NF-. kB and MAPK, prompting the suggestion that PEP-1-rpS3 can be used as a therapeutic agent against skin inflammation.

Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalToxicology
Volume276
Issue number3
DOIs
Publication statusPublished - 2010 Oct 29

Fingerprint

Tetradecanoylphorbol Acetate
Acetates
Inflammation
Mitogen-Activated Protein Kinases
Ear
Cytokines
NF-kappa B
Cyclooxygenase 2
Edema
Skin
Chemical activation
ribosomal protein S3
Peptamen
Enzymes

Keywords

  • Inflammation
  • MAPK
  • PEP-1-rpS3
  • TPA

ASJC Scopus subject areas

  • Toxicology

Cite this

Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. / Ahn, Eun Hee; Kim, Dae Won; Kang, Hye Won; Shin, Min Jae; Won, Moo Ho; Kim, Joon; Kim, Dong Joon; Kwon, Oh Shin; Kang, Tae Cheon; Han, Kyu Hyung; Park, Jinseu; Eum, Won Sik; Choi, Soo Young.

In: Toxicology, Vol. 276, No. 3, 29.10.2010, p. 192-197.

Research output: Contribution to journalArticle

Ahn, EH, Kim, DW, Kang, HW, Shin, MJ, Won, MH, Kim, J, Kim, DJ, Kwon, OS, Kang, TC, Han, KH, Park, J, Eum, WS & Choi, SY 2010, 'Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice', Toxicology, vol. 276, no. 3, pp. 192-197. https://doi.org/10.1016/j.tox.2010.08.004
Ahn, Eun Hee ; Kim, Dae Won ; Kang, Hye Won ; Shin, Min Jae ; Won, Moo Ho ; Kim, Joon ; Kim, Dong Joon ; Kwon, Oh Shin ; Kang, Tae Cheon ; Han, Kyu Hyung ; Park, Jinseu ; Eum, Won Sik ; Choi, Soo Young. / Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. In: Toxicology. 2010 ; Vol. 276, No. 3. pp. 192-197.
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