Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562

Sunyoung Park, Tae Sung Kim, Cherlhyun Kim, Seonghan Kim, Sa Ik Bang, Hyunjeong Park, Dae Ho Cho

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth. Although highly proliferative cells express transferrin and its receptor, little is known about the role of transferrin in the cellular response to cytokine production. The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess whether it could induce interleukin-18 (IL-18). Apo-transferrin enhanced IL-18 mRNA and protein and, moreover, IL-18 secretion was increased by treatment with apo-transferrin. In conclusion, apo-transferrin regulates IL-18 expression and we suggest that it is involved in cytokine production.

Original languageEnglish
Pages (from-to)315-320
Number of pages6
JournalLeukemia Research
Volume33
Issue number2
DOIs
Publication statusPublished - 2009 Feb 1

Fingerprint

Interleukin-18
Myeloid Cells
Transferrin
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cell Line
Iron
Cytokines
Transferrin Receptors
Carrier Proteins
Messenger RNA
Growth

Keywords

  • Apo-transferrin
  • Interleukin-18 (IL-18)
  • Leukemia
  • Proliferation
  • Transferrin

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562. / Park, Sunyoung; Kim, Tae Sung; Kim, Cherlhyun; Kim, Seonghan; Bang, Sa Ik; Park, Hyunjeong; Cho, Dae Ho.

In: Leukemia Research, Vol. 33, No. 2, 01.02.2009, p. 315-320.

Research output: Contribution to journalArticle

Park, Sunyoung ; Kim, Tae Sung ; Kim, Cherlhyun ; Kim, Seonghan ; Bang, Sa Ik ; Park, Hyunjeong ; Cho, Dae Ho. / Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562. In: Leukemia Research. 2009 ; Vol. 33, No. 2. pp. 315-320.
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