Transferrin saturation concentrations associated with telomeric ageing

A population-based study

Chol Shin, Inkyung Baik

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

There are limited data on the association between Fe overload and leucocyte telomere length (LTL), known as a useful biomarker of the replicative ageing of cells. The aim of the study was to evaluate associations between Fe-status biomarkers and LTL. A cross-sectional study included 1174 men and women aged 50-79 years who provided blood samples for assays of Fe-status biomarkers including ferritin, transferrin saturation (TSAT), total Fe-binding capacity (TIBC) and relative LTL. They were free of hepatitis, potential infection or Fe deficiency. In multiple linear regression analysis adjusted for potential confounding variables, log-transformed LTL was positively associated with TIBC (adjusted coefficient estimate for its highest quartile: 0·17 (se 0·03), P<0·001) and inversely associated with TSAT (adjusted coefficient estimate for its third and fourth quartiles:-0·09 (se 0·03), P<0·01). These associations were consistent after additional adjustment for serum concentrations of high-sensitivity C-reactive protein, alanine transaminase and aspartate transaminase. In particular, participants with not only abnormally high concentrations (>45 %) but also with high-normal concentrations (35-45 %) of TSAT had shorter LTL compared with those with low-normal concentrations (<30 %) (P<0·05). We also observed that less-active or obese persons with high TSAT concentrations had shorter LTL than others. Our findings that cellular ageing is influenced not only by Fe overload but also by high-normal concentrations of TSAT support the hypothesis regarding the detrimental effects of labile Fe, which has a potent pro-oxidant activity in the body.

Original languageEnglish
Pages (from-to)1693-1701
Number of pages9
JournalBritish Journal of Nutrition
Volume117
Issue number12
DOIs
Publication statusPublished - 2017 Jun 28

Fingerprint

Telomere
Transferrin
Leukocytes
Population
Biomarkers
Cell Aging
Confounding Factors (Epidemiology)
Ferritins
Hepatitis
Linear Models
Reactive Oxygen Species
Cross-Sectional Studies
Regression Analysis
Infection

Keywords

  • General populations
  • Iron overload
  • Iron status
  • Telomere length
  • Transferrin saturation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Transferrin saturation concentrations associated with telomeric ageing : A population-based study. / Shin, Chol; Baik, Inkyung.

In: British Journal of Nutrition, Vol. 117, No. 12, 28.06.2017, p. 1693-1701.

Research output: Contribution to journalArticle

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