Transformation of ginsenoside-rich fraction isolated from ginseng (Panax ginseng) leaves induces compound K

Sang Hyek Kim, Seong Yeong Kim, Ho Lee, Kyung Soo Ra, Hyung Joo Suh, Sun Young Kim, Kwang Soon Shin

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2 Citations (Scopus)


To develop the new physiologically active materials from ginseng (Panax ginseng C. A. Meyer) leaves, the ginsenoside-rich fraction (GL-1) was isolated and transformed into highly absorbable metabolites in the gastrointestinal (GI) tract. To transform the ginsenosides in GL-1 into deglycosylated ginsenosides, GL-1 was treated with organic acids (0. 1 and 1% lactic and acetic acid solutions) and fermented with isolated strains (P1-P4, and M3) from red ginseng extract for 7 days. The treatment of 0. 1% lactic acid of GL-1 induced the highest transforms of partially-deglycosylated ginsenosides such as Mc, F2, and Rg3 (intermediate metabolites). On the other hand, Compound K (Compd K, final metabolite) contents in GL-1 ferments with strain M3 showed about 6-time higher than that of control (not fermented). Consequently, the strain M3 was finally selected for the mass production of Compd K with well-absorbable property in GI tract and physiological activity.

Original languageEnglish
Pages (from-to)1179-1186
Number of pages8
JournalFood Science and Biotechnology
Issue number5
Publication statusPublished - 2011 Nov 1



  • absorbable metabolite
  • Compound K
  • ginseng leaf
  • ginsenoside-rich fraction
  • transformation

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

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