Transforming growth factor-β: Expression in normal and pathological conditions

Seong Jin Kim, David Romeo, Young Do Yoo, Keunchil Park

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Expression of the various isoforms of transforming growth factor-β (TGF-β) is differentially controlled both in vivo and in vitro. Characterization of the molecular mechanisms governing expression of TGF-β isoforms now provides a basis for understanding the selective regulation of expression of the TGF-βs by a variety of factors including oncogenes and tumor suppressor genes. In addition to transcriptional control, data suggest that expression of TGF-βs is also regulated posttranscriptionally. Regulation of TGF-βs by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Identification of these mechanisms may contribute to the understanding of the regulatory events controlling cellular proliferation and differentiation by TGF-βs and steroids/retinoids.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalHormone Research in Paediatrics
Volume42
Issue number1-2
DOIs
Publication statusPublished - 1994

Keywords

  • Expression
  • Growth factor
  • Post-transcription
  • Transcription
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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