Transforming growth factor-β: Expression in normal and pathological conditions

S. J. Kim, D. Romeo, Young Do Yoo, K. Park

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Expression of the various isoforms of transforming growth factor-β (TGF-β) is differentially controlled both in vivo and in vitro. Characterization of the molecular mechanisms governing expression of TGF-β isoforms now provides a basis for understanding the selective regulation of expression of the TGF-βs by a variety of factors including oncogenes and tumor suppressor genes. In addition to transcriptional control, data suggest that expression of TGF-βs is also regulated posttranscriptionally. Regulation of TGF-βs by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Identification of these mechanisms may contribute to the understanding of the regulatory events controlling cellular proliferation and differentiation by TGF-βs and steroids/retinoids.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalHormone Research
Volume42
Issue number1-2
Publication statusPublished - 1994 Jan 1
Externally publishedYes

Fingerprint

Transforming Growth Factors
Retinoids
Protein Isoforms
Steroids
Tumor Suppressor Genes
Oncogenes
Cell Proliferation

Keywords

  • Expression
  • Growth factor
  • Post-transcription
  • Transcription
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Endocrinology

Cite this

Transforming growth factor-β : Expression in normal and pathological conditions. / Kim, S. J.; Romeo, D.; Yoo, Young Do; Park, K.

In: Hormone Research, Vol. 42, No. 1-2, 01.01.1994, p. 5-8.

Research output: Contribution to journalArticle

Kim, S. J. ; Romeo, D. ; Yoo, Young Do ; Park, K. / Transforming growth factor-β : Expression in normal and pathological conditions. In: Hormone Research. 1994 ; Vol. 42, No. 1-2. pp. 5-8.
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