Expression of the various isoforms of transforming growth factor-β (TGF-β) is differentially controlled both in vivo and in vitro. Characterization of the molecular mechanisms governing expression of TGF-β isoforms now provides a basis for understanding the selective regulation of expression of the TGF-βs by a variety of factors including oncogenes and tumor suppressor genes. In addition to transcriptional control, data suggest that expression of TGF-βs is also regulated posttranscriptionally. Regulation of TGF-βs by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Identification of these mechanisms may contribute to the understanding of the regulatory events controlling cellular proliferation and differentiation by TGF-βs and steroids/retinoids.
- Growth factor
- Tumor suppressor gene
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism