Transforming growth factor-β1 and major depressive disorder with and without attempted suicide: Preliminary study

Hwa Young Lee, Yong Ku Kim

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)

    Abstract

    A substantial body of evidence indicates that dysregulation of the immune system is associated with suicidal behavior in major depressive disorder (MDD). Transforming growth factor (TGF)-β1 is believed to be an important factor in regulating inflammatory responses and to have anti-inflammatory effects. We aimed to identify the role of TGF-β1 on suicidal depression. The TGF-β1 polymorphisms at codons 10 and 25 were analyzed in 122 suicidal MDD patients, 61 non-suicidal MDD patients, and 120 control subjects and, among them, in vitro TGF-β1 productions were measured in 48 suicidal MDD patients, 47 non-suicidal MDD patients, and 91 control subjects. There was no genetic polymorphism at codon 25 and three genotypes at codon 10. No significant difference in the distributions of the TGF-β1 genotypes was found among the three groups. The in vitroTGF-β1 productionswere significantly higher in suicidalMDD patients (844.3±329.7 pg/ml) and in non-suicidal MDD patients (853.0±439.7 pg/ml) than in controls (683.0±397.0 pg/ml) (P=0.01). In vitro TGF-β1 productions were not significantly different among patients with any of the TGF-β1 alleles or genotypes. Our findings suggest that in vitroTGF-β1 productions play an important role onMDD, butwe found no associations between TGF-β1 and suicidal behavior.

    Original languageEnglish
    Pages (from-to)92-96
    Number of pages5
    JournalPsychiatry Research
    Volume178
    Issue number1
    DOIs
    Publication statusPublished - 2010 Jun 30

    Keywords

    • Polymorphism

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry

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