Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Je Sang Ko, Seung Min Shin, Young Mi Oh, Youn Soo Lee, Zae Yoong Ryoo, Young Han Lee, Doe Sun Na, Jin Woo Kim

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33 Citations (Scopus)

Abstract

Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

Original languageEnglish
Pages (from-to)1950-1953
Number of pages4
JournalOncogene
Volume23
Issue number10
DOIs
Publication statusPublished - 2004 Mar 11
Externally publishedYes

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Keywords

  • Breast cancer
  • HCCR-2
  • p53
  • Transgenic mouse

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Ko, J. S., Shin, S. M., Oh, Y. M., Lee, Y. S., Ryoo, Z. Y., Lee, Y. H., Na, D. S., & Kim, J. W. (2004). Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice. Oncogene, 23(10), 1950-1953. https://doi.org/10.1038/sj.onc.1207356