Transient recovery of synaptic transmission is related to rapid energy depletion during hypoxia

Joo Han Kim, Youn Kwan Park, Jong Hyun Kim, Taek Hyun Kwon, Hung Seob Chung

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Transient recovery (TR) of evoked synaptic potential during the late stage of hypoxic hypoglycemia (HH) insult was investigated in rat hippocampal slices using extracellular recording methods. TR was observed in association with a rapid deterioration of antidromic population spikes (aPSs) following HH insult. TR was not elicited in normoglycemic hypoxia (NH), in which a gradual and delayed deterioration of aPSs was noted. TR was not modulated by either Ca2+- or PKC-dependent processes. When a glycolytic inhibitor was added, NH resulted in a rapid deterioration of aPSs and prompted appearance of TR. TR was also seen in slices using lactate to generate energy via oxidative phosphorylation, when hypoxic conditions were subsequently created. Other pharmacological interventions that aimed to cause rapid deterioration of aPSs without depleting energy stores failed to reproduce TR. The evidence thus suggests that the underlying mechanisms of TR appearance during HH insult are highly correlated with rapid energy depletion.

    Original languageEnglish
    Pages (from-to)1-6
    Number of pages6
    JournalNeuroscience Letters
    Volume400
    Issue number1-2
    DOIs
    Publication statusPublished - 2006 May 29

    Keywords

    • Hippocampus
    • Hypoglycemia
    • Hypoxia
    • In vitro
    • Synaptic transmission

    ASJC Scopus subject areas

    • Neuroscience(all)

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