Transition-Metal-Free Decarboxylative Coupling Reactions for the Synthesis of Propargyl Alcohols

Francis Mariaraj Irudayanathan, Jimin Kim, Kwang Ho Song, Sunwoo Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Propargyl alcohols have been directly synthesized by decarboxylative coupling reactions with an alkynyl carboxylic acid and an aldehyde/ketone in the absence of a transition-metal catalyst. When the decarboxylative coupling reaction was conducted with Cs2CO3 in DMSO, the desired propargyl alcohols were formed in good yield. In addition, the reactions with 2,2,2-trifluoroacetophenone and aryl alkynyl carboxylic acids gave trifluoromethylated propargyl alcohols.

Original languageEnglish
Pages (from-to)1148-1154
Number of pages7
JournalAsian Journal of Organic Chemistry
Volume5
Issue number9
DOIs
Publication statusPublished - 2016 Sep 1

Keywords

  • aldehydes
  • alkynyl carboxylic acid
  • decarboxylative coupling
  • ketones
  • propargyl alcohol

ASJC Scopus subject areas

  • Organic Chemistry

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