Transmembrane protein 173 inhibits RANKL-induced osteoclast differentiation

Chung Hyeon Choe, In Sun Park, Jisang Park, Kang Yeol Yu, Hyonseok Jang, Ju Kim, Yong Suk Jang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Abstract Tmem173 was identified as a growth inhibitor associated with major histocompatibility complex (MHC) class II and a potential stimulator for IFN-β, an innate immune inducer and a negative feedback controller for RANKL-induced osteoclast differentiation of monocytic macrophage cells. In this study, we confirmed that transmembrane protein 173 (Tmem173) overexpression inhibited the expression of osteoclast-specific genes, tartrate-resistant acid phosphatase (TRAP), cathepsin K, and matrix metalloproteinase-9 (MMP-9), as well as bone resorption pit formation in RANKL-treated RAW 264.7 cells. Activation of osteoclast-specific transcription factors, c-Fos and nuclear factor of activated T cells cytoplasmic-1 (NFATc1), and RANKL-induced activation of ERK were also down-regulated by Tmem173 overexpression. Collectively, these results suggest that Tmem173 plays a regulatory role in RANKL-RANK-mediated signaling in osteoclastogenesis.

Original languageEnglish
Article number37040
Pages (from-to)836-841
Number of pages6
JournalFEBS Letters
Volume589
Issue number7
DOIs
Publication statusPublished - 2015 Mar 24

Keywords

  • Osteoclastogenesis
  • RANK ligand
  • Tartrate-resistant acid phosphatase
  • Transmembrane protein 173

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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