Transplacental transfer and age-related levels of serum IgG antibodies to the capsular polysaccharides of Streptococcus pneumoniae types 14 and 19 in Korea

Jae Kyun Yoon, Hyun Hee Lee, Byung Min Choi, Kyung Bum Kim, Hee Yeon Park, Jee Youn Lim, Ji-Tae Choung, Young Chang Tockgo

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3 Citations (Scopus)

Abstract

Little is known about the prevalence of naturally acquired IgG antibodies to the capsular polysaccharides of Streptococcus pneumoniae (pneumococcal IgG) in Korea. In the present study, we investigated transplacental transfer and age-related levels of pneumococcal IgG to provide background seroepidemiologic data for S. pneumoniae in Korea. One hundred thirty eight sera were assayed by ELISA for IgG to pneumococcal polysaccharide capsular serotypes 14 and 19, the predominant serotypes for under 15 yr of age in Korea. The subjects were divided into 7 subgroups according to age. The cord/maternal geometric mean titer of pneumococcal were 4.47 ± 5.88/5.21 ± 5.88 for serotype 14, and 4.68 ± 5.55/6.55 ± 6.92 for serotype 19 (mean ± standard deviation, μg/mL). After birth, the geometric mean titers of pneumococcal IgG for serotypes 14 and 19 expressed in μg/mL were 1.18 ± 2.12 and 1.41 ± 2.17 in the 0-6 months group, 0.27 ± 0.19 and 0.69 ± 0.93 in 7-12 months, 0.21 ± 0.22 and 0.64 ± 1.32 in 1-2 yr, 0.69 ± 0.78 and 2.65 ± 2.46 in 3-6 yr, 2.52 ± 2.72 and 8.29 ± 4.24 in 7-10 yr, respectively. In conclusion, reduced transplacental transfer and very low serum concentrations of pneumococcal IgG may contribute to the susceptibility of neonates, infants, and young children to S. pneumoniae infection.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalJournal of Korean Medical Science
Volume16
Issue number1
Publication statusPublished - 2001 Feb 1

Fingerprint

Korea
Streptococcus pneumoniae
Polysaccharides
Immunoglobulin G
Antibodies
Serum
Pneumococcal Infections
Enzyme-Linked Immunosorbent Assay
Mothers
Serogroup
Parturition
Newborn Infant

Keywords

  • Child
  • Enzyme-Linked Immunosorbent Assay
  • IgG
  • Polysaccharides
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Transplacental transfer and age-related levels of serum IgG antibodies to the capsular polysaccharides of Streptococcus pneumoniae types 14 and 19 in Korea. / Yoon, Jae Kyun; Lee, Hyun Hee; Choi, Byung Min; Kim, Kyung Bum; Park, Hee Yeon; Lim, Jee Youn; Choung, Ji-Tae; Tockgo, Young Chang.

In: Journal of Korean Medical Science, Vol. 16, No. 1, 01.02.2001, p. 9-14.

Research output: Contribution to journalArticle

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abstract = "Little is known about the prevalence of naturally acquired IgG antibodies to the capsular polysaccharides of Streptococcus pneumoniae (pneumococcal IgG) in Korea. In the present study, we investigated transplacental transfer and age-related levels of pneumococcal IgG to provide background seroepidemiologic data for S. pneumoniae in Korea. One hundred thirty eight sera were assayed by ELISA for IgG to pneumococcal polysaccharide capsular serotypes 14 and 19, the predominant serotypes for under 15 yr of age in Korea. The subjects were divided into 7 subgroups according to age. The cord/maternal geometric mean titer of pneumococcal were 4.47 ± 5.88/5.21 ± 5.88 for serotype 14, and 4.68 ± 5.55/6.55 ± 6.92 for serotype 19 (mean ± standard deviation, μg/mL). After birth, the geometric mean titers of pneumococcal IgG for serotypes 14 and 19 expressed in μg/mL were 1.18 ± 2.12 and 1.41 ± 2.17 in the 0-6 months group, 0.27 ± 0.19 and 0.69 ± 0.93 in 7-12 months, 0.21 ± 0.22 and 0.64 ± 1.32 in 1-2 yr, 0.69 ± 0.78 and 2.65 ± 2.46 in 3-6 yr, 2.52 ± 2.72 and 8.29 ± 4.24 in 7-10 yr, respectively. In conclusion, reduced transplacental transfer and very low serum concentrations of pneumococcal IgG may contribute to the susceptibility of neonates, infants, and young children to S. pneumoniae infection.",
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AU - Lee, Hyun Hee

AU - Choi, Byung Min

AU - Kim, Kyung Bum

AU - Park, Hee Yeon

AU - Lim, Jee Youn

AU - Choung, Ji-Tae

AU - Tockgo, Young Chang

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N2 - Little is known about the prevalence of naturally acquired IgG antibodies to the capsular polysaccharides of Streptococcus pneumoniae (pneumococcal IgG) in Korea. In the present study, we investigated transplacental transfer and age-related levels of pneumococcal IgG to provide background seroepidemiologic data for S. pneumoniae in Korea. One hundred thirty eight sera were assayed by ELISA for IgG to pneumococcal polysaccharide capsular serotypes 14 and 19, the predominant serotypes for under 15 yr of age in Korea. The subjects were divided into 7 subgroups according to age. The cord/maternal geometric mean titer of pneumococcal were 4.47 ± 5.88/5.21 ± 5.88 for serotype 14, and 4.68 ± 5.55/6.55 ± 6.92 for serotype 19 (mean ± standard deviation, μg/mL). After birth, the geometric mean titers of pneumococcal IgG for serotypes 14 and 19 expressed in μg/mL were 1.18 ± 2.12 and 1.41 ± 2.17 in the 0-6 months group, 0.27 ± 0.19 and 0.69 ± 0.93 in 7-12 months, 0.21 ± 0.22 and 0.64 ± 1.32 in 1-2 yr, 0.69 ± 0.78 and 2.65 ± 2.46 in 3-6 yr, 2.52 ± 2.72 and 8.29 ± 4.24 in 7-10 yr, respectively. In conclusion, reduced transplacental transfer and very low serum concentrations of pneumococcal IgG may contribute to the susceptibility of neonates, infants, and young children to S. pneumoniae infection.

AB - Little is known about the prevalence of naturally acquired IgG antibodies to the capsular polysaccharides of Streptococcus pneumoniae (pneumococcal IgG) in Korea. In the present study, we investigated transplacental transfer and age-related levels of pneumococcal IgG to provide background seroepidemiologic data for S. pneumoniae in Korea. One hundred thirty eight sera were assayed by ELISA for IgG to pneumococcal polysaccharide capsular serotypes 14 and 19, the predominant serotypes for under 15 yr of age in Korea. The subjects were divided into 7 subgroups according to age. The cord/maternal geometric mean titer of pneumococcal were 4.47 ± 5.88/5.21 ± 5.88 for serotype 14, and 4.68 ± 5.55/6.55 ± 6.92 for serotype 19 (mean ± standard deviation, μg/mL). After birth, the geometric mean titers of pneumococcal IgG for serotypes 14 and 19 expressed in μg/mL were 1.18 ± 2.12 and 1.41 ± 2.17 in the 0-6 months group, 0.27 ± 0.19 and 0.69 ± 0.93 in 7-12 months, 0.21 ± 0.22 and 0.64 ± 1.32 in 1-2 yr, 0.69 ± 0.78 and 2.65 ± 2.46 in 3-6 yr, 2.52 ± 2.72 and 8.29 ± 4.24 in 7-10 yr, respectively. In conclusion, reduced transplacental transfer and very low serum concentrations of pneumococcal IgG may contribute to the susceptibility of neonates, infants, and young children to S. pneumoniae infection.

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