Treadmill exercise increases cell proliferation in hippocampal dentate gyrus in alcohol-intoxicated rats

B. K. Yu, Bum-Chul Yoon, S. S. Kim, S. L. Chun, E. H. Kim, K. M. Kim, B. V. Lim, M. H. Jang, J. H. Chung, C. J. Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim. Effect of treadmill exercise on hippocampal cell proliferation under normal conditions has been well documented; however, this effect under alcohol intoxication conditions is not clarified, yet. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus in alcohol-intoxicated rats was investigated. Methods. Experimental design: comparative investigation on number of 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the dentate gyrus 8 days after commencement. Setting: animal laboratory. Participants: male Sprague-Dawley rats of 5 weeks in age weighing 150±10 g. Intervention: animals were divided into 4 groups: the control-rest group, the control-exercise group, the alcohol-treated-rest group, and the alcohol-treated-exercise group. Animals of the alcohol-treated groups were injected intraperitoneally with alcohol (2 g/kg) once a day for 3 days. All animals were injected BrdU (50 mg/kg) intraperitoneally, and rats of exercise groups were made to run on treadmill for 30 min each day for 5 days following alcohol administration. Measures: mean number of BrdU-positive cells in dentate gyrus was observed via immunohistochemistry. Results. Treadmill exercise significantly increased the number of BrdU-positive cells in the dentate gyrus. Also, treatment with alcohol for 3 days inhibited cell proliferation and treadmill exercise alleviated alcohol-induced inhibition of new cell formation. Conclusion. These results suggest the possibility that treadmill exercise may help in improvement following alcohol-induced brain damage.

Original languageEnglish
Pages (from-to)393-397
Number of pages5
JournalJournal of Sports Medicine and Physical Fitness
Volume43
Issue number3
Publication statusPublished - 2003 Sep 1

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Parahippocampal Gyrus
Dentate Gyrus
Alcohols
Cell Proliferation
Bromodeoxyuridine
Alcoholic Intoxication
Control Groups
Laboratory Animals
Sprague Dawley Rats
Research Design
Immunohistochemistry

Keywords

  • Alcoholism
  • Bromodeoxyuridine
  • Cell proliferation
  • Dentate gyrus
  • Exercise test
  • Immunohistochemistry

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Treadmill exercise increases cell proliferation in hippocampal dentate gyrus in alcohol-intoxicated rats. / Yu, B. K.; Yoon, Bum-Chul; Kim, S. S.; Chun, S. L.; Kim, E. H.; Kim, K. M.; Lim, B. V.; Jang, M. H.; Chung, J. H.; Kim, C. J.

In: Journal of Sports Medicine and Physical Fitness, Vol. 43, No. 3, 01.09.2003, p. 393-397.

Research output: Contribution to journalArticle

Yu, BK, Yoon, B-C, Kim, SS, Chun, SL, Kim, EH, Kim, KM, Lim, BV, Jang, MH, Chung, JH & Kim, CJ 2003, 'Treadmill exercise increases cell proliferation in hippocampal dentate gyrus in alcohol-intoxicated rats', Journal of Sports Medicine and Physical Fitness, vol. 43, no. 3, pp. 393-397.
Yu, B. K. ; Yoon, Bum-Chul ; Kim, S. S. ; Chun, S. L. ; Kim, E. H. ; Kim, K. M. ; Lim, B. V. ; Jang, M. H. ; Chung, J. H. ; Kim, C. J. / Treadmill exercise increases cell proliferation in hippocampal dentate gyrus in alcohol-intoxicated rats. In: Journal of Sports Medicine and Physical Fitness. 2003 ; Vol. 43, No. 3. pp. 393-397.
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AU - Kim, S. S.

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AU - Kim, E. H.

AU - Kim, K. M.

AU - Lim, B. V.

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AU - Chung, J. H.

AU - Kim, C. J.

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N2 - Aim. Effect of treadmill exercise on hippocampal cell proliferation under normal conditions has been well documented; however, this effect under alcohol intoxication conditions is not clarified, yet. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus in alcohol-intoxicated rats was investigated. Methods. Experimental design: comparative investigation on number of 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the dentate gyrus 8 days after commencement. Setting: animal laboratory. Participants: male Sprague-Dawley rats of 5 weeks in age weighing 150±10 g. Intervention: animals were divided into 4 groups: the control-rest group, the control-exercise group, the alcohol-treated-rest group, and the alcohol-treated-exercise group. Animals of the alcohol-treated groups were injected intraperitoneally with alcohol (2 g/kg) once a day for 3 days. All animals were injected BrdU (50 mg/kg) intraperitoneally, and rats of exercise groups were made to run on treadmill for 30 min each day for 5 days following alcohol administration. Measures: mean number of BrdU-positive cells in dentate gyrus was observed via immunohistochemistry. Results. Treadmill exercise significantly increased the number of BrdU-positive cells in the dentate gyrus. Also, treatment with alcohol for 3 days inhibited cell proliferation and treadmill exercise alleviated alcohol-induced inhibition of new cell formation. Conclusion. These results suggest the possibility that treadmill exercise may help in improvement following alcohol-induced brain damage.

AB - Aim. Effect of treadmill exercise on hippocampal cell proliferation under normal conditions has been well documented; however, this effect under alcohol intoxication conditions is not clarified, yet. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus in alcohol-intoxicated rats was investigated. Methods. Experimental design: comparative investigation on number of 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the dentate gyrus 8 days after commencement. Setting: animal laboratory. Participants: male Sprague-Dawley rats of 5 weeks in age weighing 150±10 g. Intervention: animals were divided into 4 groups: the control-rest group, the control-exercise group, the alcohol-treated-rest group, and the alcohol-treated-exercise group. Animals of the alcohol-treated groups were injected intraperitoneally with alcohol (2 g/kg) once a day for 3 days. All animals were injected BrdU (50 mg/kg) intraperitoneally, and rats of exercise groups were made to run on treadmill for 30 min each day for 5 days following alcohol administration. Measures: mean number of BrdU-positive cells in dentate gyrus was observed via immunohistochemistry. Results. Treadmill exercise significantly increased the number of BrdU-positive cells in the dentate gyrus. Also, treatment with alcohol for 3 days inhibited cell proliferation and treadmill exercise alleviated alcohol-induced inhibition of new cell formation. Conclusion. These results suggest the possibility that treadmill exercise may help in improvement following alcohol-induced brain damage.

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KW - Bromodeoxyuridine

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