Treadmill exercise increases cell proliferation in hippocampal dentate gyrus in alcohol-intoxicated rats

B. K. Yu, Bum-Chul Yoon, S. S. Kim, S. L. Chun, E. H. Kim, K. M. Kim, B. V. Lim, M. H. Jang, J. H. Chung, C. J. Kim

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Abstract

Aim. Effect of treadmill exercise on hippocampal cell proliferation under normal conditions has been well documented; however, this effect under alcohol intoxication conditions is not clarified, yet. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus in alcohol-intoxicated rats was investigated. Methods. Experimental design: comparative investigation on number of 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the dentate gyrus 8 days after commencement. Setting: animal laboratory. Participants: male Sprague-Dawley rats of 5 weeks in age weighing 150±10 g. Intervention: animals were divided into 4 groups: the control-rest group, the control-exercise group, the alcohol-treated-rest group, and the alcohol-treated-exercise group. Animals of the alcohol-treated groups were injected intraperitoneally with alcohol (2 g/kg) once a day for 3 days. All animals were injected BrdU (50 mg/kg) intraperitoneally, and rats of exercise groups were made to run on treadmill for 30 min each day for 5 days following alcohol administration. Measures: mean number of BrdU-positive cells in dentate gyrus was observed via immunohistochemistry. Results. Treadmill exercise significantly increased the number of BrdU-positive cells in the dentate gyrus. Also, treatment with alcohol for 3 days inhibited cell proliferation and treadmill exercise alleviated alcohol-induced inhibition of new cell formation. Conclusion. These results suggest the possibility that treadmill exercise may help in improvement following alcohol-induced brain damage.

Original languageEnglish
Pages (from-to)393-397
Number of pages5
JournalJournal of Sports Medicine and Physical Fitness
Volume43
Issue number3
Publication statusPublished - 2003 Sep 1

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Keywords

  • Alcoholism
  • Bromodeoxyuridine
  • Cell proliferation
  • Dentate gyrus
  • Exercise test
  • Immunohistochemistry

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Yu, B. K., Yoon, B-C., Kim, S. S., Chun, S. L., Kim, E. H., Kim, K. M., Lim, B. V., Jang, M. H., Chung, J. H., & Kim, C. J. (2003). Treadmill exercise increases cell proliferation in hippocampal dentate gyrus in alcohol-intoxicated rats. Journal of Sports Medicine and Physical Fitness, 43(3), 393-397.